hu-210
hu-210 structure
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Common Name | hu-210 | ||
|---|---|---|---|---|
| CAS Number | 112830-95-2 | Molecular Weight | 386.567 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 470.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C25H38O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 238.1±28.7 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.
Cell Death Differ. 22 , 1618-29, (2015) The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain. In particular, the CB1 receptor is highly expressed in the basal ganglia, mostl... |
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Validation and application of an UPLC-MS/MS method for the quantification of synthetic cannabinoids in urine samples and analysis of seized materials from the Portuguese market.
Forensic Sci. Int. 243 , 117-25, (2014) An UPLC-MS/MS method using ESI+ionization and MRM was developed and fully validated according to international guidelines for the qualitative and quantitative analysis of nine synthetic cannabinoids and/or their metabolites in urine samples (1mL). Prior to ex... |
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Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior.
J. Neurosci. 35 , 13975-88, (2015) Adolescence is characterized by drastic behavioral adaptations and comprises a particularly vulnerable period for the emergence of various psychiatric disorders. Growing evidence reveals that the pathophysiology of these disorders might derive from aberration... |
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Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.
Mol. Pharmacol. 88 , 368-79, (2015) CB1 cannabinoid receptors (CB1Rs) are attractive therapeutic targets for numerous central nervous system disorders. However, clinical application of cannabinoid ligands has been hampered owing to their adverse on-target effects. Ligand-biased signaling from, ... |
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Synthetic and endogenous cannabinoids protect retinal neurons from AMPA excitotoxicity in vivo, via activation of CB1 receptors: Involvement of PI3K/Akt and MEK/ERK signaling pathways.
Exp. Eye Res. 136 , 45-58, (2015) Cannabinoids have been suggested to protect retinal ganglion cells in different models of toxicity, but their effects on other retinal neurons are poorly known. We investigated the neuroprotective actions of the endocannabinoid N-arachidonoyl ethanolamine (An... |
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Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth.
Elife 3 , e03159, (2014) Endocannabinoids are recently recognized regulators of brain development, but molecular effectors downstream of type-1 cannabinoid receptor (CB1R)-activation remain incompletely understood. We report atypical coupling of neuronal CB1Rs, after activation by en... |
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Effect of the synthetic cannabinoid HU-210 on quorum sensing and on the production of quorum sensing-mediated virulence factors by Vibrio harveyi.
BMC Microbiol. 15 , 159, (2015) Bacterial populations communicate through the cell density-dependent mechanism of quorum sensing (QS). Vibrio harveyi, one of the best studied model organisms for QS, was used to explore effects of the synthetic cannabinoid HU-210 on QS and different QS-regul... |
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Identification of raloxifene as a novel CB2 inverse agonist.
Biochem. Biophys. Res. Commun. 435(1) , 76-81, (2013) The purpose of the current study was to apply a high throughput assay to systematically screen a library of food and drug administration (FDA)-approved drugs as potential ligands for the cannabinoid receptor 2 (CB2). A cell-based, homogenous time resolved flu... |
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Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms.
Am. J. Physiol. Gastrointest. Liver Physiol. 304(2) , G181-92, (2013) The endocannabinoid system has been shown to mediate beneficial effects on gastrointestinal inflammation via cannabinoid receptors 1 (CB(1)) and 2 (CB(2)). These receptors have also been reported to activate the MAP kinases p38 and c-Jun NH(2)-terminal kinase... |
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G-protein inhibition profile of the reported Gq/11 inhibitor UBO-QIC.
Biochem. Biophys. Res. Commun. 469 , 101-7, (2015) UBO-QIC (FR900359) is the only currently available Gq/11 protein inhibitor. However, its characterization has not been published, and we thus set out to do this. Gi, Gs and Gq protein-mediated responses were assessed utilizing endogenous or heterologously exp... |