Thioperamide (maleate)
Thioperamide (maleate) structure
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Common Name | Thioperamide (maleate) | ||
|---|---|---|---|---|
| CAS Number | 148440-81-7 | Molecular Weight | 408.515 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H28N4O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Highly potent and selective ligands for histamine H3-receptors.
Nature 327 , 117, (1987) New drugs selective for histamine H3-receptors can be used to establish that these receptors are involved in the feedback control of histamine synthesis and release, and to demonstrate their distribution in the brain and peripheral tissues. These drugs provid... |
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Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain.
J. Neurochem. 52 , 1388, (1989) To study the feedback control by histamine (HA) H3-receptors on the synthesis and release of HA at nerve endings in the brain, the effects of a potent and selective H3-agonist, (R)-alpha-methylhistamine, and an H3-antagonist, thioperamide, on the pargyline-in... |
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Effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions in mice.
Eur. J. Pharmacol. 234(1) , 129-33, (1993) The effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions was studied in mice. Thioperamide significantly and dose dependently decreased the duration of each phase of convulsion and raised the electroconvulsive thresh... |
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Effects of thioperamide, a histamine H3-receptor antagonist, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice.
Life Sci. 57(23) , 2137-44, (1995) We examined the effects of thioperamide and (R)-alpha-methylhistamine, a histamine H3-receptor antagonist and an agonist, respectively, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice. Thioperamide alone slightly improved th... |
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Biphasic effects of orexin-A on autonomic nerve activity and lipolysis.
Neurosci. Lett. 444(2) , 166-71, (2008) Previously, we showed that orexin-A, a 33-aa peptide, influences renal sympathetic nerve activity. Because the autonomic nervous system plays an important role in the regulation of lipid metabolism, we investigated the in vivo effects of orexin-A on the sympa... |
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Regulation of sympathetic nerve activity by L-carnosine in mammalian white adipose tissue.
Neurosci. Lett. 441(1) , 100-4, (2008) Previously, we showed that l-carnosine, a bioactive dipeptide, influences the sympathetic nerve activity innervating kidney and brown adipose tissue. Because the autonomic nervous system plays an important role in the regulation of lipid metabolism, we invest... |
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Effects of histamine H3-receptor ligands on various biochemical indices of histaminergic neuron activity in rat brain.
Eur. J. Pharmacol. 164 , 1, (1989) The interaction of the potent histamine H3-receptor ligands i.e. (R)alpha-methylhistamine, an agonist, and thioperamide, an antagonist, with the three classes of cerebral histamine receptors was studied in vitro and in vivo. The histamine-induced stimulation ... |