Phenylgalactoside
Phenylgalactoside structure
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Common Name | Phenylgalactoside | ||
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| CAS Number | 2818-58-8 | Molecular Weight | 256.25200 | |
| Density | 1.451 g/cm3 | Boiling Point | 482.1ºC at 760 mmHg | |
| Molecular Formula | C12H16O6 | Melting Point | 153-155 °C(lit.) | |
| MSDS | USA | Flash Point | 245.4ºC | |
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Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation.
Pharmacol. Biochem. Behav. 133 , 122-31, (2015) Fibroblast growth factor 21 (FGF21) is a hormone secreted predominantly in the liver, pancreas and adipose tissue. Recently, it has been reported that FGF21-Transgenic mice can extend their lifespan compared with wild type counterparts. Thus, we hypothesize t... |
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Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
J. Med. Chem. 53 , 4779-92, (2010) FimH-mediated cellular adhesion to mannosylated proteins is critical in the ability of uropathogenic E. coli (UPEC) to colonize and invade the bladder epithelium during urinary tract infection. We describe the discovery and optimization of potent small-molecu... |
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Transdifferentiation of mouse adipose-derived stromal cells into acinar cells of the submandibular gland using a co-culture system.
Exp. Cell Res. 334 , 160-72, (2015) A loss of salivary gland function often occurs after radiation therapy in head and neck tumors, though secretion of saliva by the salivary glands is essential for the health and maintenance of the oral environment. Transplantation of salivary acinar cells (AC... |
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Drosophila KASH-domain protein Klarsicht regulates microtubule stability and integrin receptor localization during collective cell migration.
Dev. Biol. 407 , 103-14, (2015) During collective migration of the Drosophila embryonic salivary gland, cells rearrange to form a tube of a distinct shape and size. Here, we report a novel role for the Drosophila Klarsicht-Anc-Syne Homology (KASH) domain protein Klarsicht (Klar) in the regu... |
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COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation.
J. Exp. Med. 204 , 2053-61, (2007) Although cyclooxygenase (COX)-2 inhibitors (coxibs) are effective in controlling inflammation, pain, and tumorigenesis, their use is limited by the recent revelation of increased adverse cardiovascular events. The mechanistic basis of this side effect is not ... |
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FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.
J. Med. Chem. 53 , 8627-41, (2010) Urinary tract infection (UTI) by uropathogenic Escherichia coli (UPEC) is one of the most common infections, particularly affecting women. The interaction of FimH, a lectin located at the tip of bacterial pili, with high mannose structures is critical for the... |
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Comparison of the X-gal- and P-gal-based systems for screening of mutant lambda lacZ phages originating from the transgenic mouse strain 40.6.
Mutat. Res. 360(2) , 101-6, (1996) The recent introduction of the phenyl-beta-D-galactopyranoside (P-gal)-based positive-selection system for screening of lambda lacZ phages originating from the lambda lacZ transgenic mouse (Muta Mouse) has made the determination of mutant frequencies (MF) a m... |
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A bisubstrate analog inhibitor for alpha(1----2)-fucosyltransferase.
J. Biol. Chem. 264(29) , 17174-81, (1989) Porcine submaxillary beta-galactoside alpha(1----2)-fucosyltransferase is known to transfer a fucosyl residue from guanosine 5'-diphosphofucose (GDP-fucose) to the 2-OH group of beta-D-galactopyranosides with inversion of configuration at the fucopyranosyl an... |
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The mechanism of initiation of chondroitin sulphate synthesis by beta-D-galactosides.
Biochem. Int. 21(6) , 1161-8, (1990) Embryonic chicken cartilage was incubated in vitro with phenyl-beta-[6-3H]galactoside and cycloheximide. Free chondroitin sulphate chains initiated by galactoside were isolated and degraded to yield 3-O-beta-D-glucuronosyl D-galactose (GlcA-Gal) derived from ... |
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m-Fluorotyrosine substitution in beta-galactosidase; evidence for the existence of a catalytically active tyrosine.
Biochem. Biophys. Res. Commun. 131(2) , 675-80, (1985) The pH profiles of beta-galactosidase, having tyr replaced by m-fluorotyrosine, were compared to those of normal enzyme. The inflection point on the alkaline side was lowered about 1.5 pH units in the fluoro-enzyme, corresponding to the difference in the phen... |