ACTH (18-39) (human)
ACTH (18-39) (human) structure
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Common Name | ACTH (18-39) (human) | ||
|---|---|---|---|---|
| CAS Number | 53917-42-3 | Molecular Weight | 2465.67000 | |
| Density | 1.49g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C112H165N27O36 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.
Nat. Commun. 5 , 5369, (2014) Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we use a reductionist cell-free antigen-processing system composed of defined components. We use the sy... |
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Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility.
J. Immunol. 194(4) , 1446-53, (2015) B lymphocytes exploit macroautophagy to capture cytoplasmic and nuclear proteins within autophagosomes. Fusion of autophagosomes with lysosomes and endosomes facilitates content proteolysis, with the resulting peptides selectively binding MHC class II (MHC II... |
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Enantioseparation of basic chiral compounds on a clindamycin phosphate-silica/zirconia hybrid monolith by capillary electrochromatography.
J. Chromatogr. A. 1356 , 289-93, (2014) An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clindamycin phosphate (CLIP) as a chiral selector. A sol solution... |
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Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nat. Commun. 6 , 6771, (2015) Lymphatic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletional tolerance. LECs express MHC-II molecules, suggesting they might also tolerize CD4 T cells. We demonstrate that when β-galactosidase (β-gal) is expr... |
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The SH3 regulatory domain of the hematopoietic cell kinase Hck binds ELMO via its polyproline motif.
FEBS Open Bio 5 , 99-106, (2015) Eukaryotic EnguLfment and cell MOtility (ELMO) proteins form an evolutionary conserved family of regulators involved in small GTPase dependent actin remodeling processes that regulates the guanine exchange factor activity of some of the Downstream Of CrK (DOC... |
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HLA class II peptide tetramers vs allergen-induced proliferation for identification of allergen-specific CD4 T cells.
Allergy 70(1) , 49-58, (2014) Fluorescence-labeled MHC class II/peptide tetramer complexes are considered as optimal tools to characterize allergen-specific CD4(+) T cells, but this technique is restricted to frequently expressed HLA class II molecules and knowledge of immunodominant epit... |
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HLA-DMA polymorphisms differentially affect MHC class II peptide loading.
J. Immunol. 194(2) , 803-16, (2015) During the adaptive immune response, MHCII proteins display antigenic peptides on the cell surface of APCs for CD4(+) T cell surveillance. HLA-DM, a nonclassical MHCII protein, acts as a peptide exchange catalyst for MHCII, editing the peptide repertoire. Alt... |
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Proximity ligation assay evaluates IDH1R132H presentation in gliomas.
J. Clin. Invest. 125(2) , 593-606, (2015) For a targeted cancer vaccine to be effective, the antigen of interest needs to be naturally processed and presented on MHC by the target cell or an antigen-presenting cell (APC) in the tumor stroma. The presence of these characteristics is often assumed base... |
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Influence of a 1-h immobilization stress on sleep and CLIP (ACTH(18-39)) brain contents in adrenalectomized rats.
Brain Res. 853(2) , 323-9, (2000) Basal sleep amounts in adrenalectomized rats (AdX), as compared to intact animals, exhibit a significant increase in slow-wave sleep (SWS), a tendency towards an increase in paradoxical sleep (PS), and circadian rhythms (SWS and PS) flattened in amplitude. An... |
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An immunocytochemical mapping of ACTH/CLIP in the cat diencephalon.
J. Chem. Neuroanat. 11(3) , 191-7, (1996) Using an indirect immunoperoxidase technique, the location of cell bodies and fibres containing adrenocorticotropin hormone/corticotropin-like intermediate lobe peptide (ACTH/CLIP) was studied in the cat diencephalon. Immunoreactivity was observed in several ... |