ACTH (18-39) (human)

Modify Date: 2024-01-01 23:43:41

ACTH (18-39) (human) Structure
ACTH (18-39) (human) structure
Common Name ACTH (18-39) (human)
CAS Number 53917-42-3 Molecular Weight 2465.67000
Density 1.49g/cm3 Boiling Point N/A
Molecular Formula C112H165N27O36 Melting Point N/A
MSDS USA Flash Point N/A

 Use of ACTH (18-39) (human)


Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is is produced in the melanotrophs of the intermediate lobe of the pituitary.

 Names

Name Adrenocorticotropic Hormone
Synonym More Synonyms

 ACTH (18-39) (human) Biological Activity

Description Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is is produced in the melanotrophs of the intermediate lobe of the pituitary.
Related Catalog
In Vitro The ACTH family of polypeptides consists of ACTH(1-39) (adrenocorticotropin), ACTH (1-13)amide (α-melanotropin;α-MSH); and ACTH (18-39) (corticotropinlike intermediate lobe peptide, CLIP). These polypeptides are derived from a common precursor, proopiomelanocortin. In corticotropic cells of the pars distalis, proopiomelanocortin (POMC) undergoes a series of proteolytic cleavage reactions to yield ACTH (1-39) as a major end product. However, in the melanotropic cells of the pars intermedia, an additional set of proteolytic reactions results in the conversion of ACTH (1-39) to ACTH (1-13) amide and ACTH (18-39). In several species of vertebrates, ACTH (1-13) amide undergoes end product modification to yield mono- and diacetylated forms ofα-MSH as major end products in the pars intermedia[1].
References

[1]. Dores RM, et al. Analysis of ACTH-related and CLIP-related peptides partially purified from the pituitary of the Australian lungfish, Neoceratodus forsteri. Gen Comp Endocrinol. 1990 Jul;79(1):64-73.

 Chemical & Physical Properties

Density 1.49g/cm3
Molecular Formula C112H165N27O36
Molecular Weight 2465.67000
Exact Mass 2464.19000
PSA 1006.02000
LogP 1.91620
Index of Refraction 1.665
Storage condition -20℃

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles36

More Articles
Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.

Nat. Commun. 5 , 5369, (2014)

Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we use a reductionist cell-free antigen-proc...

Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility.

J. Immunol. 194(4) , 1446-53, (2015)

B lymphocytes exploit macroautophagy to capture cytoplasmic and nuclear proteins within autophagosomes. Fusion of autophagosomes with lysosomes and endosomes facilitates content proteolysis, with the ...

Enantioseparation of basic chiral compounds on a clindamycin phosphate-silica/zirconia hybrid monolith by capillary electrochromatography.

J. Chromatogr. A. 1356 , 289-93, (2014)

An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clinda...

 Synonyms

CLIP
ProteoMass™ ACTH Fragment 18-39 MALDI-MS
Adrenocorticotropic hormone fragment 18-39
ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE: RPVKVYPNGAEDESAEAFPLEF
ACTH (18-39) (HUMAN)
Adrenocorticotropic Hormone (ACTH) (18-39), human
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