ACTH (18-39) (human)

Names

[ Name ]:
ACTH (18-39) (human)

[Synonym ]:
CLIP
ProteoMass™ ACTH Fragment 18-39 MALDI-MS
Adrenocorticotropic hormone fragment 18-39
ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE: RPVKVYPNGAEDESAEAFPLEF
ACTH (18-39) (HUMAN)
Adrenocorticotropic Hormone (ACTH) (18-39), human

Biological Activity

[Description]:

Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is is produced in the melanotrophs of the intermediate lobe of the pituitary.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

Peptides

[In Vitro]

The ACTH family of polypeptides consists of ACTH(1-39) (adrenocorticotropin), ACTH (1-13)amide (α-melanotropin;α-MSH); and ACTH (18-39) (corticotropinlike intermediate lobe peptide, CLIP). These polypeptides are derived from a common precursor, proopiomelanocortin. In corticotropic cells of the pars distalis, proopiomelanocortin (POMC) undergoes a series of proteolytic cleavage reactions to yield ACTH (1-39) as a major end product. However, in the melanotropic cells of the pars intermedia, an additional set of proteolytic reactions results in the conversion of ACTH (1-39) to ACTH (1-13) amide and ACTH (18-39). In several species of vertebrates, ACTH (1-13) amide undergoes end product modification to yield mono- and diacetylated forms ofα-MSH as major end products in the pars intermedia[1].

[References]

[1]. Dores RM, et al. Analysis of ACTH-related and CLIP-related peptides partially purified from the pituitary of the Australian lungfish, Neoceratodus forsteri. Gen Comp Endocrinol. 1990 Jul;79(1):64-73.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.49g/cm3

[ Molecular Formula ]:
C₁₁₂H₁₆₅N₂₇O₃₆

[ Molecular Weight ]:
2465.67000

[ Exact Mass ]:
2464.19000

[ PSA ]:
1006.02000

[ LogP ]:
1.91620

[ Index of Refraction ]:
1.665

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.

Nat. Commun. 5 , 5369, (2014)

Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we use a reductionist cell-free antigen-proc...

Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility.

J. Immunol. 194(4) , 1446-53, (2015)

B lymphocytes exploit macroautophagy to capture cytoplasmic and nuclear proteins within autophagosomes. Fusion of autophagosomes with lysosomes and endosomes facilitates content proteolysis, with the ...

Enantioseparation of basic chiral compounds on a clindamycin phosphate-silica/zirconia hybrid monolith by capillary electrochromatography.

J. Chromatogr. A. 1356 , 289-93, (2014)

An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clinda...