Chlorodifluoroacetophenone

Chlorodifluoroacetophenone Structure
Chlorodifluoroacetophenone structure
Common Name Chlorodifluoroacetophenone
CAS Number 384-67-8 Molecular Weight 190.574
Density 1.3±0.1 g/cm3 Boiling Point 199.1±35.0 °C at 760 mmHg
Molecular Formula C8H5ClF2O Melting Point N/A
MSDS Chinese USA Flash Point 74.2±25.9 °C
Symbol GHS07
GHS07
Signal Word Warning

2-Chloro-2,2-difluoroacetophenone: a non-ODS-based difluorocarbene precursor and its use in the difluoromethylation of phenol derivatives.

J. Org. Chem. 71 , 9845, (2006)

A novel and non-ODS-based (ODS = ozone-depleting substance) preparation of 2-chloro-2,2-difluoroacetophenone (1) was achieved in high yield by using 2,2,2-trifluoroacetophenone as the starting material. Compound 1 was found to act as a good difluorocarbene re...