Actein
Actein structure
|
Common Name | Actein | ||
|---|---|---|---|---|
| CAS Number | 18642-44-9 | Molecular Weight | 676.834 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C37H56O11 | Melting Point | 246-250ºC | |
| MSDS | N/A | Flash Point | N/A | |
|
Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa.
J. Nat. Prod. 73(12) , 2024-8, (2010) Black cohosh (Actaea racemosa) is a frequently used herbal remedy for the treatment of mild climacteric symptoms. In the present study, the modulation of γ-aminobutryic acid (GABA)-induced chloride currents (I(GABA)) through GABA type A (GABA(A)) receptors by... |
|
|
Growth inhibitory activity of extracts and compounds from Cimicifuga species on human breast cancer cells.
Phytomedicine 15(6-7) , 504-11, (2008) The purpose of this report is to explore the growth inhibitory effect of extracts and compounds from black cohosh and related Cimicifuga species on human breast cancer cells and to determine the nature of the active components. Black cohosh fractions enriched... |
|
|
Studies on the Chinese crude drug "shoma." IX. Three novel cyclolanostanol xylosides, cimicifugosides H-1, H-2 and H-5, from cimicifuga rhizome.
Chem. Pharm. Bull. 43(5) , 771-6, (1995) Three new cyclolanostanol xylosides were isolated from a batch of commercial Cimicifuga Rhizome, cimicifugoside H-1 (1), C35H52O9, mp 260-262 degrees C, [alpha]D -43.5 degrees, cimicifugoside H-2 (2), C35H54O10, mp 227-229 degrees C, [alpha]D -38.8 degrees, a... |
|
|
Actein and a fraction of black cohosh potentiate antiproliferative effects of chemotherapy agents on human breast cancer cells.
Planta Med. 72(13) , 1200-6, (2006) The purpose of this study was to determine whether the triterpene glycosides present in black cohosh enhance the growth inhibitory effects of specific breast cancer chemotherapy agents. Black cohosh roots and rhizomes were extracted with methanol (MeOH)/water... |
|
|
Pregnane X receptor-mediated induction of Cyp3a by black cohosh.
Xenobiotica 41(2) , 112-23, (2011) Black cohosh (BC) has been widely applied for the treatment of menopausal symptoms. However, increasing concerns about herb-drug interactions demand the need for studies on the influence of BC on cytochrome 450. Cyp3a11 in liver was induced by 7-fold in wild-... |
|
|
Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.
Bioorg. Med. Chem. Lett. 14(5) , 1329-32, (2004) Actein (1), a tetracyclic triterpenoid from the rhizome of Cimicifuga racemosa (black cohosh), and 82 related triterpenoid and steroidal saponins isolated from higher plants were evaluated for anti-HIV activity as a continuing study to discover potential anti... |
|
|
The growth inhibitory effect of actein on human breast cancer cells is associated with activation of stress response pathways.
Int. J. Cancer 121(9) , 2073-83, (2007) Previous studies indicate that the triterpene glycoside actein from the herb black cohosh inhibits growth of human breast cancer cells. This study seeks to identify genes altered in human breast cancer cells by treatment with actein, using gene expression ana... |
|
|
Methods of phytochemical standardisation of rhizoma Cimicifugae racemosae.
Phytochem. Anal. 15(2) , 100-8, (2004) The methanolic extract of roots of Cimicifuga racemosa and its methanolysis products have been analysed by GC-MS. 2-Hexylcyclopropaneoctanoic acid (9,10-methylenehexadecanoic acid) was found to be the marker most specific for the identification for this herb.... |
|
|
Actein inhibits the Na+-K+-ATPase and enhances the growth inhibitory effect of digitoxin on human breast cancer cells.
Biochem. Biophys. Res. Commun. 375(4) , 608-13, (2008) The Na+K+-ATPase is a known target of cardiac glycosides such as digitoxin and ouabain. We determined that the enzyme also is a target of the structurally-related triterpene glycoside actein, present in the herb black cohosh. Actein's inhibition of Na+-K+-ATP... |
|
|
Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats.
Fundam. Clin. Pharmacol. 23(3) , 311-21, (2009) The purpose of this study was to assess in rats the pharmacological parameters and effects on gene expression in the liver of the triterpene glycoside actein. Actein, an active component from the herb black cohosh, has been shown to inhibit the proliferation ... |