Kinetin riboside
Kinetin riboside structure
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Common Name | Kinetin riboside | ||
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| CAS Number | 4338-47-0 | Molecular Weight | 347.326 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 683.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C15H17N5O5 | Melting Point | 152-154ºC | |
| MSDS | Chinese USA | Flash Point | 367.3±34.3 °C | |
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High-internal-phase-emulsion polymeric monolith coupled with liquid chromatography-electrospray tandem mass spectrometry for enrichment and sensitive detection of trace cytokinins in plant samples.
Anal. Bioanal. Chem 407 , 6071-9, (2015) High-internal-phase-emulsion polymers (polyHIPEs) show great promise as solid-phase-extraction (SPE) materials because of the tremendous porosity and highly interconnected framework afforded by the high-internal-phase-emulsion (HIPE) technique. In this work, ... |
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Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity.
Bioorg. Med. Chem. 16 , 3848-65, (2008) Conformationally constrained analogue synthesis was undertaken to aid in pharmacophore mapping and 3D-QSAR analysis of nitrobenzylmercaptopurine riboside (NBMPR) congeners as equilibriative nucleoside transporter 1 (ENT1) inhibitors. In our previous study [J.... |
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Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.
J. Med. Chem. 51 , 4260-9, (2008) A series of cycloalkyl, bicycloalkyl, aryl, and heteroaryl N (6)-substituted derivatives of the antitumor agent 3'- C-methyladenosine (3'-Me-Ado), an inhibitor of the alpha Rnr1 subunit of mammalian ribonucleotide reductase (RR), were synthesized. The cytotox... |
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Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity.
J. Clin. Invest. 118 , 1750-1764, (2008) Knockout and transgenic studies in mice demonstrate that normal somatic tissues redundantly express 3 cyclin D proteins, whereas tumor cells seem dependent on a single overexpressed cyclin D. Thus, selective suppression of the individual cyclin D deregulated ... |
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Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells.
Cancer Lett. 261 , 37-45, (2008) Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were up... |
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Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones.
Cell Growth Differ. 13 , 19-26, (2002) We examined the effects of various adenine analogues on the growth and differentiation of human myeloid leukemia HL-60 cells. Some of these analogues inhibit growth and induce nitroblue tetrazolium reducing activity in HL-60 cells. Cytokinins such as kinetin,... |
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Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells.
Int. J. Biol. Macromol. 34 , 271-275, (2004) The cytotoxicity of two plant hormone compounds, kinetin and kinetin riboside, was studied on tumour cells, by colony forming assay with increased amount of cytotoxic molecules. The concentration of inhibitor required to reduce cell growth to 50% was determin... |
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Differentiation of human myeloid leukemia cells by plant redifferentiation-inducing hormones.
Leukemia Lymphoma 43 , 1729-1735, (2002) Although differentiation therapy for patients with acute promyelocytic leukemia (APL) using all-trans retinoic acid (ATRA) has now been established, acute myeloid leukemia (AML) patients with other than APL only show a limited clinical response to ATRA. We mu... |
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MMP9 mediates MICA shedding in human osteosarcomas.
Cell Biol. Int. 35 , 569-74, (2011) The MICA (MHC class I chain-related molecule A) is a ligand for the activating immunoreceptor NKG2D (natural killer group 2, member D). NKG2D recognizes MICA expressing at the cell surface for cell elimination. Although MICA is overexpressed in many kinds of ... |
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Effects of kinetin riboside on proliferation and proapoptotic activities in human normal and cancer cell lines. Dudzik P, Dulińska-Litewka J, Wyszko E, et al.
J. Cell Biol. 112 , 2115-2124, (2011)
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