1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl-1-(2-propyn-1-yl)-
1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl-1-(2-propyn-1-yl)- structure
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Common Name | 1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl-1-(2-propyn-1-yl)- | ||
|---|---|---|---|---|
| CAS Number | 14114-46-6 | Molecular Weight | 218.21200 | |
| Density | 1.31g/cm3 | Boiling Point | 443.9ºC at 760mmHg | |
| Molecular Formula | C10H10N4O2 | Melting Point | 204-205ºC | |
| MSDS | Chinese USA | Flash Point | 222.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele.
Biomed Res. Int. 2015 , 248976, (2015) Neuronal apoptosis inhibitory protein (NAIP) and survivin might play an important role in testicular function. We investigated the effect of PDRN, an agonist of adenosine A2A receptor, on testicular NAIP and survivin expression in an experimental model of var... |
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Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
Vis. Neurosci. 31(3) , 237-43, (2014) Electrical coupling of photoreceptors through gap junctions suppresses voltage noise, routes rod signals into cone pathways, expands the dynamic range of rod photoreceptors in high scotopic and mesopic illumination, and improves detection of contrast and smal... |
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Adenosine reduces GABAergic IPSC frequency via presynaptic A₁ receptors in hypothalamic paraventricular neurons projecting to rostral ventrolateral medulla.
Neurosci. Lett. 490(1) , 63-7, (2011) Adenosine is an inhibitory modulator of neuronal transmission, including GABAergic transmission in the hypothalamus. It is known that the local GABAergic inputs tonically inhibit the hypothalamic paraventricular neurons projecting to the rostral ventrolateral... |
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Presynaptic inhibition of GABAergic synaptic transmission by adenosine in mouse hypothalamic hypocretin neurons.
Neuroscience 201 , 46-56, (2012) Hypocretin neurons in the lateral hypothalamus, a new wakefulness-promoting center, have been recently regarded as an important target involved in endogenous adenosine-regulating sleep homeostasis. The GABAergic synaptic transmissions are the main inhibitory ... |
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Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation in experimental periodontitis.
J. Clin. Periodontol. 40(1) , 26-32, (2013) Adenosine receptors modulate inflammation in periodontal tissues. No data are available regarding the effects of adenosine A(2A) receptor stimulation in experimental periodontitis (EPD). The aim of this study was to investigate the effects of polynucleotides ... |
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A combination of ischemic preconditioning and allopurinol protects against ischemic injury through a nitric oxide-dependent mechanism.
Nitric Oxide 26(1) , 1-8, (2012) This study examined the cytoprotective mechanisms of a combination of ischemic preconditioning (IPC) and allopurinol against liver injury caused by ischemia/reperfusion (I/R). Allopurinol (50mg/kg) was intraperitoneally administered 18 and 1h before sustained... |
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Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.
J. Neurosci. 32(40) , 13945-55, (2012) After hypoxia, a critical adverse outcome is the inability to create new memories. How anterograde amnesia develops or resolves remains elusive, but a link to brain-based IL-1 is suggested due to the vital role of IL-1 in both learning and brain injury. We ex... |
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Adenosine A2 receptor-mediated regulation of renal hemodynamics and glomerular filtration rate is abolished in diabetes.
Adv. Exp. Med. Biol. 765 , 225-30, (2013) Alterations in glomerular filtration rate (GFR) are one of the earliest indications of altered kidney function in diabetes. Adenosine regulates GFR through tubuloglomerular feedback mechanism acting on adenosine A1 receptor. In addition, adenosine can directl... |
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Adenosine A2 receptor activation attenuates afferent arteriolar autoregulation during adenosine receptor saturation in rats.
Hypertension 50(4) , 744-9, (2007) Adenosine is an important paracrine agent regulating renal hemodynamics via adenosine A1 and A2 receptors. To determine the interactions between adenosine A1 and A2 receptors and the possible role of adenosine as a modulator of afferent arteriolar autoregulat... |
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The role of the basal forebrain adenosine receptors in sleep homeostasis.
Neuroreport 20(11) , 1013-8, (2009) Multiple studies indicate that adenosine released in the basal forebrain during prolonged wakefulness could affect recovery sleep. It is still unclear which of adenosine receptors provide its sleep-modulating effects in the basal forebrain. We infused adenosi... |