8-Aminoadenosine
8-Aminoadenosine structure
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Common Name | 8-Aminoadenosine | ||
|---|---|---|---|---|
| CAS Number | 3868-33-5 | Molecular Weight | 282.26 | |
| Density | 2.25g/cm3 | Boiling Point | 747.1ºC at 760mmHg | |
| Molecular Formula | C10H14N6O4 | Melting Point | 180-185ºC dec. | |
| MSDS | Chinese USA | Flash Point | 405.6ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Property editing of peptide nucleic acids (PNA): gem-dimethyl, cyanuryl and 8-aminoadenine PNAs.
Nucleic Acids Symp. Ser. (51) , 17-8, (2007) We herein describe the introduction of gem-dimethyl substitution into the aminoethylglycyl backbone of PNA to impart steric constraint and pre-organise PNA for selective recognition of nucleic acids. Introduction of cyanuric acid and 8-aminoadenine as pyrimid... |
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Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine.
J. Biol. Chem. 284(39) , 26816-30, (2009) Multiple myeloma, an incurable plasma cell malignancy, is characterized by altered cellular metabolism and resistance to apoptosis. Recent connections between glucose metabolism and resistance to apoptosis provide a compelling rationale for targeting metaboli... |
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8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: role in induction of apoptosis in multiple myeloma.
Mol. Cancer Ther. 4(4) , 569-77, (2005) Multiple myeloma is a slowly proliferating B-cell malignancy that accumulates apoptosis-resistant and replication-quiescent cell populations, posing a challenge for current chemotherapeutics that target rapidly replicating cells. Multiple myeloma remains an i... |
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8-amino-adenosine is a potential therapeutic agent for multiple myeloma.
Mol. Cancer Ther. 3(11) , 1411-20, (2004) Multiple myeloma (MM) is a malignancy of clonal B-cells that accounts for 10% of all hematologic malignancies. We have shown previously that a novel purine analogue, 8-chloro-adenosine, has significant activity for MM in preclinical studies.Using MM cell line... |
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Mechanisms of cell death of chronic lymphocytic leukemia lymphocytes by RNA-directed agent, 8-NH2-adenosine.
Clin. Cancer Res. 11(18) , 6745-52, (2005) To determine if RNA-directed nucleoside analogue, 8-NH(2)-adenosine, induces cell death and if that is accompanied with transcription inhibition of the key survival factors of chronic lymphocytic leukemia (CLL) cells.Primary lymphocytes from CLL patients were... |
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8-Amino-adenosine inhibits multiple mechanisms of transcription.
Mol. Cancer Ther. 9(1) , 236-45, (2010) Roscovitine and flavopiridol suppress cyclin-dependent kinase 7 (CDK7) and CDK9 activity resulting in transcription inhibition, thus providing an alternative mechanism to traditional genotoxic chemotherapy. These agents have been effective in slow or nonrepli... |
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Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms.
PLoS ONE 7(7) , e41455, (2012) The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the context of B-lineage lymphoid malignancies by our laboratories due to the selective cytotoxicity they exhibit toward multiple myeloma (MM), chronic lymphocytic leu... |
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Multifaceted actions of 8-amino-adenosine kill BCR-ABL positive cells.
Leuk. Lymphoma 53(10) , 2024-32, (2012) Survival of chronic myelogenous leukemia (CML) cells is dependent on BCR-ABL kinase, the activity of which is contingent on the level of BCR-ABL protein and the availability of adenosine triphosphate (ATP). We hypothesized that 8-amino-adenosine (8-amino-Ado)... |
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Binding isotherms of nucleosides and polynucleotides measured by continuous ultrafiltration at constant volume: a rapid and precise technique.
Biochemistry 21(1) , 57-62, (1982) Equilibrium binding isotherms have been measured as a function of temperature for the interaction of 2- and 8-aminoadenosine with poly(U) by continuous, constant-volume ultrafiltration. An analytical method is described for determining the entire isotherm in ... |
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Non-tyrosine kinase inhibitor-targeting of BCR-ABL expressing cells.
Leuk. Lymphoma 53(10) , 1857-8, (2012)
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