Ferric ammonium citrate
Ferric ammonium citrate structure
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Common Name | Ferric ammonium citrate | ||
|---|---|---|---|---|
| CAS Number | 1185-57-5 | Molecular Weight | 261.975 | |
| Density | 1.8 g/cm3 (20ºC) | Boiling Point | 197ºC | |
| Molecular Formula | C6H8FeNO7 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Iron overload causes oxidative stress and impaired insulin signaling in AML-12 hepatocytes.
Dig. Dis. Sci. 58(7) , 1899-908, (2013) Iron overload is associated with increased severity of nonalcoholic fatty liver disease (NAFLD) including progression to nonalcoholic steatohepatitis and hepatocellular carcinoma.To identify potential role(s) of iron in NAFLD, we measured its effects on pathw... |
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Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells.
Neurochem. Res. 35(8) , 1259-68, (2010) The oligodendroglial cell line OLN-93 was used as model system to investigate the consequences of iron deprivation or iron excess on cell proliferation. Presence of ferric or ferrous iron chelators inhibited the proliferation of OLN-93 cells in a time and con... |
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Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter.
Gut 95 , 1261-8, (2010) Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma vi... |
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Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload.
Life Sci. 92(4-5) , 298-304, (2013) Although iron overload induces oxidative stress and brain mitochondrial dysfunction, and is associated with neurodegenerative diseases, brain mitochondrial iron uptake has not been investigated. We determined the role of mitochondrial calcium uniporter (MCU) ... |
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Iron overload inhibits calcification and differentiation of ATDC5 cells.
J. Biochem. 151(1) , 109-14, (2012) There is a little information about the effects of iron overload on cartilage metabolism. In the present study, we examined the effects of excess iron on the differentiation and mineralization of cultured chondrocytes, ATDC5 cells. We used ferric ammonium cit... |
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Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells.
Neurotoxicology 32(1) , 75-82, (2011) Excessive neuronal iron has been proposed to contribute to the pathology of several neurodegenerative diseases including Alzheimer's and Parkinson's diseases. This work characterized human neuroblastoma IMR-32 cells exposure to ferric ammonium citrate (FAC) a... |
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Paradoxical role of prion protein aggregates in redox-iron induced toxicity.
PLoS ONE 5(7) , e11420, (2010) Imbalance of iron homeostasis has been reported in sporadic Creutzfeldt-Jakob-disease (sCJD) affected human and scrapie infected animal brains, but the contribution of this phenotype to disease associated neurotoxicity is unclear.Using cell models of familial... |
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Efficiency of ferritin as an MRI reporter gene in NPC cells is enhanced by iron supplementation.
J. Biomed. Biotechnol. 2012 , 434878, (2012) An emerging MRI reporter, ferritin heavy chain (FTH1), is recently applied to enhance the contrast and increase the sensitivity of MRI in the monitoring of solid tumors. However, FTH1-overexpression-related cytotoxicity is required to be explored.By using the... |
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Iron and holotransferrin induce cAMP-dependent differentiation of Schwann cells.
Neurochem. Int. 61(5) , 798-806, (2012) The differentiation of myelin-forming Schwann cells (SC) is completed with the appearance of myelin proteins MBP and P(0) and a concomitant downregulation of markers GFAP and p75NTR, which are expressed by immature and adult non-myelin-forming SC. We have pre... |
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Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia.
Neurosci. Lett. 500(1) , 36-40, (2011) Activation of microglia could be beneficial and yet simultaneously harmful depending upon nature of pathological milieu. Regardless of disease-specific etiology, iron accumulation, particularly in activated microglia, is a notable feature associated with a se... |