Ergosterol
Ergosterol structure
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Common Name | Ergosterol | ||
|---|---|---|---|---|
| CAS Number | 57-87-4 | Molecular Weight | 396.648 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 501.5±39.0 °C at 760 mmHg | |
| Molecular Formula | C28H44O | Melting Point | 156-158 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 216.3±19.3 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Comparison of the antifungal efficacy of terbinafine hydrochloride and ciclopirox olamine containing formulations against the dermatophyte Trichophyton rubrum in an infected nail plate model.
Mol. Pharm. 11(7) , 1991-6, (2014) Onychomycosis is a fungal infection mostly induced by dermatophytes such as Trichophyton rubrum. Due to slow nail growth, the treatment takes 3-9 months depending on the nail size and infected area. Hence, high efficacy of the active ingredient without system... |
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The mannoprotein TIR3 (CAGL0C03872g) is required for sterol uptake in Candida glabrata.
Biochim. Biophys. Acta 1851(2) , 141-51, (2015) Sterol uptake in the pathogenic fungus, Candida glabrata, occurs via the sterol transporter, CgAus1p. Azole inhibition of sterol biosynthesis can under certain circumstances be reversed by adding exogenously sterol. Here we demonstrate that the CgTIR3 (CAGL0C... |
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Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation.
Biol. Chem. 395(7-8) , 801-12, (2014) As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factors constitutes an experimental challenge, however, because b... |
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Biomass estimation during macro-scale solid-state fermentation of basidiomycetes using established and novel approaches.
Bioprocess Biosyst. Eng. 38 , 1313-23, (2015) Solid-state fermentation (SSF) has been utilised in food production for millennia and is well suited for the cultivation of basidiomycetes, due to the robustness of the process and the possibility of using lignocellulose as the substrate. Basidiomycetes produ... |
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FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.
Nat. Commun. 6 , 8613, (2015) FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (S... |
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Phytochemical Characterization of Veronica officinalis L., V. teucrium L. and V. orchidea Crantz from Romania and Their Antioxidant and Antimicrobial Properties.
Int. J. Mol. Sci. 16 , 21109-27, (2015) Aerial parts of Veronica species are used in Romanian traditional medicine for the treatment of various conditions like kidney diseases, cough, and catarrh, and are known for their wound-healing properties. In the present study, the phenolic and sterolic cont... |
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Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane.
Bioorg. Med. Chem. 23 , 5782-8, (2015) Amphotericin B (AmB) is a polyene macrolide antibiotic widely used to treat mycotic infections. In this paper, we focus on the role of the polyol moiety of AmB in sterol selectivity using 7-oxo-AmB, 7α-OH-AmB, and 7β-OH-AmB. The 7-OH analogs were prepared fro... |
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The role of sterols in the lipid vesicle response induced by the pore-forming agent nystatin.
Biochim. Biophys. Acta 1838(10) , 2635-45, (2014) The influences of ergosterol and cholesterol on the activity of the nystatin were investigated experimentally in a POPC model membrane as well as theoretically. The behavior of giant unilamellar vesicles (GUVs) under osmotic stress due to the formation of tra... |
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A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast.
PLoS ONE 7(11) , e49004, (2012) Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation. Thus, it is difficult to study the effects of the inhibition of various enzymes on the inter... |
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Anti-HCV activity of the Chinese medicinal fungusCordyceps militaris
Biochem. Biophys. Res. Commun. 447(2) , 341-5, (2014) • Cordyceps militaris (CM) had a moderate anti-HCV activity for RNA replication. • Cordycepin is a responsible compound for the anti-HCV activity of CM. • CM would be a useful anti-HCV agent in combination with IFN-α and/or RBV. |