Cyclophosphamide (hydrate)
Cyclophosphamide (hydrate) structure
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Common Name | Cyclophosphamide (hydrate) | ||
|---|---|---|---|---|
| CAS Number | 6055-19-2 | Molecular Weight | 279.101 | |
| Density | N/A | Boiling Point | 336.1ºC at 760 mmHg | |
| Molecular Formula | C7H17Cl2N2O3P | Melting Point | 49-51 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | >230 °F | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM.
Sci. Rep. 5 , 13001, (2015) We have previously demonstrated that activation of the cyclic adenosine monophosphate (cAMP) pathway kills multiple myeloma (MM) cells both in vitro and in vivo. In the present study we have investigated the potential of enhancing the killing of MM cell lines... |
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Antitumor effects and immune regulation activities of a purified polysaccharide extracted from Juglan regia.
Int. J. Biol. Macromol. 72 , 771-5, (2014) A water-soluble polysaccharide, named as JRP1, was extracted and fractioned from the epicarp of immature fruit of Juglans mandshurica Maxim. The determination of the monosaccharide composition in JRP1 with gas chromatography (GC) showed that JRP1 was composed... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis.
Phytother Res. 29(3) , 357-65, (2015) Studies have shown chemopreventive and/or chemotherapeutic effects of several curcumin-based combinatorial treatments on colorectal cancer cells. However, their in vivo effects remain unclear. This study has demonstrated the therapeutic effect of curcumin and... |
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Effects of the total saponins from Dioscorea nipponica on immunoregulation in aplastic anemia mice.
Am. J. Chin. Med. 43(2) , 289-303, (2015) Dioscorea nipponica Makino, a popular folk medicine, exerts anti-inflammation properties. The present study investigated the therapeutic effect of the total saponins from Dioscorea nipponica Makino (TSDN) on aplastic anemia (AA) and possible immune regulation... |
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An improved and versatile immunosuppression protocol for the development of tumor xenograft in mice.
Anticancer Res. 34(12) , 7177-83, (2014) The objective of the present study was to evaluate the efficacy of a simple, versatile and cost-effective immunosuppression protocol, using cyclosporine, ketoconazole and cyclophosphamide drug regimen to develop human tumor xenograft in mice.Cyclosporine, ket... |
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Protective efficacy of passive immunization with monoclonal antibodies in animal models of H5N1 highly pathogenic avian influenza virus infection.
PLoS Pathog. 10(6) , e1004192, (2014) Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype often cause severe pneumonia and multiple organ failure in humans, with reported case fatality rates of more than 60%. To develop a clinical antibody therapy, we generated a human-mouse chim... |
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Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes.
J. Invest. Dermatol. 135(1) , 142-50, (2014) Patients with altered skin immunity, such as individuals with atopic dermatitis (AD), can have a life-threatening disruption of the epidermis known as eczema vaccinatum after vaccinia virus (VV) infection of the skin. Here, we sought to better understand the ... |
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A molecular analysis provides novel insights into androgen receptor signalling in breast cancer.
PLoS ONE 10(3) , e0120622, (2015) Androgen Receptor (AR) is an essential transcription factor for the development of secondary sex characteristics, spermatogenesis and carcinogenesis. Recently AR has been implicated in the development and progression of breast and prostate cancers. Although s... |
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Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewing's family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression.
Clin. Cancer Res. 21(5) , 1139-50, (2015) To determine the pharmacokinetics and the antitumor activity in pediatric cancer models of MM-398, a nanoliposomal irinotecan (nal-IRI).Mouse plasma and tissue pharmacokinetics of nal-IRI and the current clinical formulation of irinotecan were characterized. ... |