Lacidipine
Lacidipine structure
|
Common Name | Lacidipine | ||
|---|---|---|---|---|
| CAS Number | 103890-78-4 | Molecular Weight | 455.543 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 558.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C26H33NO6 | Melting Point | 174-175°C | |
| MSDS | Chinese USA | Flash Point | 291.5±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats.
Pak. J. Biol. Sci. 16(21) , 1353-7, (2013) Calcium channel blockers are increasingly used for the treatment of hypertension. Hypertension is an important risk factor for liver damage and several other circulatory abnormalities. The aim of this study was to determine the effects of lacidipine in a irra... |
|
|
Effect of long-term antihypertensive treatment on white-coat hypertension.
Hypertension 64(6) , 1388-98, (2014) Limited evidence is available on the extent and frequency by which antihypertensive treatment lowers office blood pressure (BP) in white-coat hypertension (WCH). Data are even more scanty and discrepant on the corresponding effect on ambulatory BP (ABP). In t... |
|
|
Ordered mesoporous silica material SBA-15: loading of new calcium channel blocker--lacidipine.
J. Microencapsul. 30(1) , 21-7, (2013) Mesoporous material SBA-15 of hexagonal structure was synthesised and its usefulness as a carrier for a poorly soluble drug--lacidipine (LA)--was tested. The source of silica was tetraethyl orthosilicate (TEOS) and the structure ordering agent was non-ionic s... |
|
|
The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats.
Surg. Today 42(11) , 1051-60, (2012) To investigate the effects of metyrosine, lacidipine, clonidine, and moxonidine on the renal damage in rats with unilateral ureteral ligation by examining the histological evidence of parenchymal damage and tubular dilatation, as well as biochemical changes i... |
|
|
The cardiac and vascular effects of lacidipine.
J. Cardiovasc. Pharmacol. 25 Suppl 3 , S1-5, (1995) The vasoprotective activity of lacidipine has been demonstrated both in animals and humans. Results from several studies indicate that vital organ perfusion is maintained, or even increased, during lacidipine administration. Left ventricular hypertrophy (LVH)... |
|
|
Discrepant regulation of QT (QTc) interval duration by calcium channel blockade and angiotensin converting enzyme inhibition in experimental hypertension.
Basic Clin Pharmacol Toxicol. 111(4) , 279-88, (2012) Antihypertensive treatment may reduce prolonged QT duration in hypertension. Generally, the reductions of blood pressure and/or of cardiac mass are believed to be the responsible factors. However, drugs are not equivalent in QT modulation despite similar anti... |
|
|
Comparing effects of lacidipine, ramipril, and valsartan against experimentally induced myocardial infarcted rats.
Cardiovasc. Toxicol. 12(2) , 166-74, (2012) In this study, the effects of lacidipine (LAC), ramipril (RAM), and valsartan (VAL) on biochemical and histopathologic changes in heart tissue were studied in rats with isoproterenol-induced (ISO-induced) myocardial infarction (MI). LAC, RAM, and VAL had been... |
|
|
Development and validation of a reversed-phase ultra-performance liquid chromatographic method for assay of lacidipine and related substances.
J. AOAC Int. 94(6) , 1800-6, (2011) A simple isocratic, RP-ultra-performance LC method was developed and validated for the determination of lacidipine, three process impurities formed during synthesis, and three degradation products present in drug substance and the drug product. An efficient c... |
|
|
Considerations in the development of an in vitro dissolution condition for lacidipine tablets: in vivo pharmacokinetic evaluation.
Drug Dev. Ind. Pharm. 38(9) , 1099-106, (2012) In this study, a new discriminative dissolution condition for lacidipine tablets was developed by the established in vitro-in vivo relationship. Series of dissolution media of phosphate buffer solution (PBS) covering the pH range of 1-7.2 and pH 6.8 PBS conta... |
|
|
LC-MS/MS determination and pharmacokinetic study of lacidipine in human plasma.
Biomed. Chromatogr. 27(7) , 838-45, (2013) A robust, specific and fully validated LC-MS/MS method as per general practices of industry has been developed for estimation of lacidipine (LAC) with 100 μL of human plasma using lacidipine-(13) C8 as an internal standard (IS). The API-4000 LC-MS/MS was oper... |