Sertraline hydrochloride
Sertraline hydrochloride structure
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Common Name | Sertraline hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 79559-97-0 | Molecular Weight | 342.690 | |
| Density | N/A | Boiling Point | 416.3ºC at 760 mmHg | |
| Molecular Formula | C17H18Cl3N | Melting Point | 246-249°C | |
| MSDS | Chinese USA | Flash Point | 205.6ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Ultrasound effects on brain-targeting mannosylated liposomes: in vitro and blood-brain barrier transport investigations.
Drug Des. Devel. Ther. 9 , 3885-98, (2015) Delivering drugs to intracerebral regions can be accomplished by improving the capacity of transport through blood-brain barrier. Using sertraline as model drug for brain targeting, the current study aimed at modifying its liposomal vesicles with mannopyranos... |
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Gingival pain: an unusual side effect of ziprasidone.
BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013) The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyr... |
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Behavioral and biochemical responses in freshwater fish Carassius auratus exposed to sertraline.
Chemosphere 135 , 146-55, (2015) Sertraline is one of the most commonly prescribed selective serotonin reuptake inhibitors and is frequently detected in the aquatic environment. However, knowledge regarding relationships among molecular or biochemical endpoints involved in modes of action (M... |
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A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.
Sci. Transl. Med. 7 , 290ra89, (2015) Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical ... |
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Different serum BDNF levels in depression: results from BDNF studies in FYR Macedonia and Bulgaria.
Psychiatr. Danub. 25(2) , 123-7, (2013) A growing body of evidence shows that brain-derived neurotrophic factor (BDNF) plays a role in depressive disorder. Serum BDNF levels are lower in depressed patients and they increase after a long course of antidepressant treatment. Our study aims to test the... |
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Development and validation of LC-MSMS assay for the determination of the prodrug dabigatran etexilate and its active metabolites in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 989 , 37-45, (2015) Dabigatran etexilate (DABE) is a low-molecular-weight prodrug that is converted after oral administration to dabigatran (DAB)-a directly acting oral anticoagulant. In this study, an LC-MSMS assay was developed and validated for the determination of DABE, free... |
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Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats.
J. Ethnopharmacol. 155(3) , 1473-82, (2014) Schisandra chinensis (SC), officially listed as a sedative and tonic in the Chinese Pharmacopoeia, has been used as a common component in various prescriptions in Traditional Chinese Medicine (TCM) and more recently in western medicine for its antihepatotoxic... |
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Sertraline induces endoplasmic reticulum stress in hepatic cells.
Toxicology 322 , 78-88, (2014) Sertraline is used for the treatment of depression, and is also used for the treatment of panic, obsessive-compulsive, and post-traumatic stress disorders. Previously, we have demonstrated that sertraline caused hepatic cytotoxicity, with mitochondrial dysfun... |
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Antidepressants.
Nursing 43(9) , 64, (2013)
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Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature 503(7474) , 141-5, (2013) The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) a... |