Nicardipine Hydrochloride
Nicardipine Hydrochloride structure
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Common Name | Nicardipine Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 54527-84-3 | Molecular Weight | 515.986 | |
| Density | N/A | Boiling Point | 603.4ºC at 760 mmHg | |
| Molecular Formula | C26H30ClN3O6 | Melting Point | 176-1780C | |
| MSDS | Chinese USA | Flash Point | 318.7ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni.
PLoS Negl. Trop. Dis. 9 , e0003962, (2015) As plans to expand mass drug treatment campaigns to fight schistosomiasis form, worries about reliance on praziquantel as the sole available treatment motivate the investigation for novel antischistosomal compounds. Drug repurposing might be an inexpensive an... |
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Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases.
J. Pharm. Biomed. Anal. 111 , 333-43, (2015) Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both analytically and on a preparative scale. The use of SFC as a... |
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The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression.
Sci. Rep. 5 , 14086, (2015) The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering t... |
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Plasticity of calcium signaling cascades in human embryonic stem cell-derived neural precursors.
Stem Cells Dev. 22(10) , 1506-21, (2013) Human embryonic stem cell-derived neural precursors (hESC NPs) are considered to be a promising tool for cell-based therapy in central nervous system injuries and neurodegenerative diseases. The Ca(2+) ion is an important intracellular messenger essential for... |
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Decreased serum osmolality promotes ductus arteriosus constriction.
Cardiovasc. Res. 104(2) , 326-36, (2014) At birth, dynamic changes occur in serum components and haemodynamics, such as closure of the ductus arteriosus (DA). A previous study demonstrated that, in full-term human neonates, serum osmolality decreased transiently after birth, but recovered over the n... |
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Lysophosphatidylcholine protects cerebellar granule neurons from apoptotic cell death.
J. Neurosci. Res. 87 , 190-9, (2009) Cultured cerebellar granule neurons (CGNs) undergo apoptosis when deprived of depolarizing stimulation and provide an in vitro model system with which to study the effects of neurotrophic substances. Our previous results showed that secretory phospholipases A... |
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Physical compatibility of cisatracurium with selected drugs during simulated Y-site administration.
Am. J. Health Syst. Pharm. 72(6) , 483-6, (2015) The physical compatibility of cisatracurium with selected drugs during simulated Y-site administration was studied.Study drugs were selected based on the lack of physical compatibility data with cisatracurium and their use in intensive care units. Test admixt... |
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Effect of Retroperitoneal Lavage with Normal Saline Containing Adrenaline on Carbon Dioxide Absorption in Patients Undergoing Retroperitoneal Laparoscopic Surgery.
J Laparoendosc Adv Surg Tech A 25 , 903-7, (2015) To determine the effect of lavage with adrenaline solution on CO2 absorption during retroperitoneal laparoscopic surgery.Sixty patients scheduled to undergo retroperitoneal laparoscopic surgery were divided into an AD group (lavage with normal saline containi... |
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Effect of calcium channel antagonists nifedipine and nicardipine on rat cytochrome P-450 2B and 3A forms.
J. Pharmacol. Exp. Ther. 290 , 1436-1441, (1999) Calcium channel antagonists are widely prescribed for treatment of hypertension. In this study, we examined whether treatment with the calcium channel antagonists, nicardipine, nifedipine or diltiazem, alters cytochrome P-450 2B or 3A (CYP2B or CYP3A, respect... |
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Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway.
J. Physiol. 527 , 433-44, (2000) The small G-protein Ras, a critical component in the signalling pathways regulating cell growth, is involved in the tonic upregulation of voltage-dependent calcium channels (VDCCs) in rat sensory neurones. To investigate which downstream effector(s) of Ras is... |