Amlexanox
Amlexanox structure
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Common Name | Amlexanox | ||
|---|---|---|---|---|
| CAS Number | 68302-57-8 | Molecular Weight | 298.293 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 570.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H14N2O4 | Melting Point | >3000C | |
| MSDS | USA | Flash Point | 298.5±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery.
J. Interferon Cytokine Res. 35(3) , 143-56, (2015) Hydroxychloroquine (HCQ) is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus (DE... |
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Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization.
Mol. Pharmacol. 88 , 347-56, (2015) There is ongoing debate about the role of G protein-coupled receptor kinases (GRKs) in agonist-induced desensitization of the μ-opioid receptor (MOPr) in brain neurons. In the present paper, we have used a novel membrane-permeable, small-molecule inhibitor of... |
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Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.
Nat. Commun. 6 , 6074, (2015) Development of an immune or autoimmune response involves T-cell activation in lymphoid organs and subsequent migration to peripheral tissues. Here we show that T-cell-specific ablation of the kinase TBK1 promotes T-cell activation but causes retention of effe... |
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A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.
Nat. Commun. 6 , 6047, (2015) The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhi... |
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7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.
PLoS ONE 9(7) , e100985, (2014) The cholesterol oxide 7-ketocholesterol (7KCh) has been implicated in numerous age-related diseases such as atherosclerosis, Alzheimer's disease, Parkinson's disease, cancer and age-related macular degeneration. It is formed by the autooxidation of cholestero... |
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Transcription Factor Runx3 Is Induced by Influenza A Virus and Double-Strand RNA and Mediates Airway Epithelial Cell Apoptosis.
Sci. Rep. 5 , 17916, (2015) Influenza A virus (IAV) targets airway epithelial cells and exploits the host cell machinery to replicate, causing respiratory illness in annual epidemics and pandemics of variable severity. The high rate of antigenic drift (viral mutation) and the putative a... |
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Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.
Sci. Rep. 5 , 13575, (2015) The activity of protein kinases IKK-ε and TANK-binding kinase 1 (TBK1) has been shown to be associated with inflammatory diseases. As an inhibitor of IKK-ε and TBK1, amlexanox is an anti-inflammatory, anti-allergic, immunomodulator and used for treatment of u... |
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A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs.
J. Pharmacol. Sci. 101(4) , 350-5, (2006) We established a new and facile model to investigate allergic mechanism and assess the effect of antiallergic compounds. Male Wistar rats were actively or passively sensitized. Active sensitization was performed by injection of both dinitrophenylated-ovalbumi... |
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Rescue of nonsense mutations by amlexanox in human cells.
Orphanet J. Rare Dis. 7 , 58, (2012) Nonsense mutations are at the origin of many cancers and inherited genetic diseases. The consequence of nonsense mutations is often the absence of mutant gene expression due to the activation of an mRNA surveillance mechanism called nonsense-mediated mRNA dec... |
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Turning off the inflammatory, but not the metabolic, flames.
Nat. Med. 19(3) , 265-7, (2013)
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