Fingolimod hydrochloride
Fingolimod hydrochloride structure
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Common Name | Fingolimod hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 162359-56-0 | Molecular Weight | 343.932 | |
| Density | 1.016g/cm3 | Boiling Point | 479.5ºC at 760 mmHg | |
| Molecular Formula | C19H34ClNO2 | Melting Point | 102-107ºC | |
| MSDS | Chinese USA | Flash Point | 243.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Fingolimod and risk of varicella-zoster virus infection: back to the future with an old infection and a new drug.
JAMA Neurol. 72(1) , 10-3, (2015)
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Varicella-zoster virus infections in patients treated with fingolimod: risk assessment and consensus recommendations for management.
JAMA Neurol. 72(1) , 31-9, (2015) Varicella-zoster virus (VZV) infections increasingly are reported in patients with multiple sclerosis (MS) and constitute an area of significant concern, especially with the advent of more disease-modifying treatments in MS that affect T-cell-mediated immunit... |
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Initial lymphocyte count and low BMI may affect fingolimod-induced lymphopenia.
Neurology 83(23) , 2153-7, (2014) To assess whether pretreatment-lymphocyte counts, treatment before fingolimod, age, sex, or body mass index (BMI) affects the risk of fingolimod-induced lymphopenia in patients with relapsing-remitting multiple sclerosis (RRMS).Data were obtained from a Germa... |
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[Multiple sclerosis and pregnancy].
Duodecim. 129(14) , 1457-64, (2013) Multiple sclerosis will usually calm down during pregnancy, but the number of relapses again increases immediately after childbirth. Among the conventional immunomodulatory drugs, there is experience already for over 15 years of the use of interferon-beta and... |
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Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction.
J. Urol. 191(5 Suppl) , 1508-16, (2014) The S1P signaling pathway represents an important potential target for the modulation of tissue inflammation/injury. The immunomodulator FTY720, also known as fingolimod, is a potent agonist for multiple S1P receptors that was approved by the Food and Drug Ad... |
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Switching from natalizumab to fingolimod in multiple sclerosis: a French prospective study.
JAMA Neurol. 71(4) , 436-41, (2014) The safety and efficacy of switching from natalizumab to fingolimod have not yet been evaluated in a large cohort of patients with multiple sclerosis (MS) to our knowledge.To collect data from patients with MS switching from natalizumab to fingolimod.The Enqu... |
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The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.
Biochim. Biophys. Acta 1843(9) , 1969-77, (2014) We recently discovered that the protein phosphatase 2A (PP2A) B55α subunit (PPP2R2A) is under-expressed in primary blast cells and is unfavorable for remission duration in AML patients. In this study, reverse phase protein analysis (RPPA) of 230 proteins in 5... |
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FTY720 protects retinal ganglion cells in experimental glaucoma.
Invest. Ophthalmol. Vis. Sci. 55(5) , 3060-6, (2014) To investigate the neuroprotective effects of sphingosine-1-phosphate (S1P) analogue fingolimod (FTY720) in experimental glaucoma in rats.A unilateral chronic ocular hypertensive model was established by injections of microbeads into the anterior eye chamber ... |
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FTY720 attenuates hypoxia-reoxygenation-induced apoptosis in cardiomyocytes.
Exp. Mol. Pathol. 97(2) , 218-24, (2014) FTY720, sphingosine 1 phosphate (S1P) receptor agonist, is a potent immunosuppressive agent. Numerous studies have documented a relationship between S1P and cardioprotection. We therefore hypothesized that a S1P analogue FTY720 would attenuate hypoxia/reoxyge... |
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Modulation of IL-33/ST2-TIR and TLR signalling pathway by fingolimod and analogues in immune cells.
Scand. J. Immunol. 80(6) , 398-407, (2014) For the immune modulatory drug fingolimod (FTY720), lymphocyte sequestration has been extensively studied and accepted as mode of action. Further, direct effects on immune cell signalling are incompletely understood. Herein, we used the parent drug and newly ... |