Chlormethine hydrochloride
Chlormethine hydrochloride structure
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Common Name | Chlormethine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 55-86-7 | Molecular Weight | 192.514 | |
| Density | 1.106g/cm3 | Boiling Point | 110.3ºC at 760 mmHg | |
| Molecular Formula | C5H12Cl3N | Melting Point | 108-111 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 20.5ºC | |
| Symbol |
GHS05, GHS06, GHS08 |
Signal Word | Danger | |
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Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.
Hum. Mol. Genet. 24(3) , 698-713, (2015) Congenital brain and craniofacial defects often occur together as a consequence of their developmental dependency on common progenitor tissue interactions and signaling pathways during embryogenesis. A classic example of this is perturbation of midline embryo... |
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Lethality of PAK3 and SGK2 shRNAs to human papillomavirus positive cervical cancer cells is independent of PAK3 and SGK2 knockdown.
PLoS ONE 10(1) , e0117357, (2015) The p21-activated kinase 3 (PAK3) and the serum and glucocorticoid-induced kinase 2 (SGK2) have been previously proposed as essential kinases for human papillomavirus positive (HPV+) cervical cancer cell survival. This was established using a shRNA knockdown ... |
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J. Mol. Biol. 427(4) , 924-42, (2015) The human pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor to a wide variety of xenobiotics and regulates expression of several drug metabolizing enzymes and transporters. We have generated "Adnectins", derived from 10th ... |
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Paracrine factors secreted by umbilical cord-derived mesenchymal stem cells induce angiogenesis in vitro by a VEGF-independent pathway.
Stem Cells Dev. 24(4) , 437-50, (2015) Improvement in angiogenesis using mesenchymal stem cells (MSCs) is evolving as an option in patients with vascular insufficiencies. The paracrine factors secreted by MSCs have been attributed to the angiogenic response. This study was conducted to identify th... |
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Carbohydr. Polym. 122 , 437-45, (2015) The impact of starch granule structure on amylose (AM) and amylopectin (AP) chain reactivities was investigated over a 24h period in a model reaction system utilizing a fluorescent probe [DTAF, 5-(4,6-dichlorotriazinyl)aminofluorescein] as a reagent. For vari... |
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Appl. Microbiol. Biotechnol. 99 , 10237-47, (2015) Accurate determination of fatty acid contents is routinely required in microalgal and yeast biofuel studies. A method of rapid in situ fatty acid methyl ester (FAME) derivatization directly from wet fresh microalgal and yeast biomass was developed in this stu... |
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The trenbolone acetate affects the immune system in rainbow trout, Oncorhynchus mykiss.
Aquat. Toxicol. 163 , 109-20, (2015) In aquatic systems, the presence of endocrine-disrupting chemicals (EDC) can disrupt the reproductive function but also the immune system of wildlife. Some studies have investigated the effects of androgens on the fish immune parameters but the mechanisms by ... |
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A cell-ECM screening method to predict breast cancer metastasis.
Integr. Biol. (Camb.) 7(2) , 198-212, (2015) Breast cancer preferentially spreads to the bone, brain, liver, and lung. The clinical patterns of this tissue-specific spread (tropism) cannot be explained by blood flow alone, yet our understanding of what mediates tropism to these physically and chemically... |
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Integrative Genomics Implicates EGFR as a Downstream Mediator in NKX2-1 Amplified Non-Small Cell Lung Cancer.
PLoS ONE 10 , e0142061, (2015) NKX2-1, encoding a homeobox transcription factor, is amplified in approximately 15% of non-small cell lung cancers (NSCLC), where it is thought to drive cancer cell proliferation and survival. However, its mechanism of action remains largely unknown. To ident... |
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A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.
Nat. Commun. 6 , 7286, (2015) During angiogenesis, Rho-GTPases influence endothelial cell migration and cell-cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using an organotypic system that recapitulates dis... |