Trilostane
Trilostane structure
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Common Name | Trilostane | ||
|---|---|---|---|---|
| CAS Number | 13647-35-3 | Molecular Weight | 329.433 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 497.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H27NO3 | Melting Point | 264ºC | |
| MSDS | Chinese USA | Flash Point | 254.8±28.7 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Disturbances in production of progesterone and their implications in plant studies.
Steroids 96 , 153-63, (2015) Progesterone is a mammalian hormone that has also been discovered in plants but its physiological function in plants is not explained. Experiments using inhibitors of progesterone synthesis and binding would be useful in studies on the significance of this co... |
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Guanosine triphosphate can directly regulate cortisol production by activating Ca(2+)-messenger systems in bovine adrenal fasciculata cells.
Endocr. J. 63 , 77-85, (2016) Adenosine triphosphate (ATP) is known to stimulate cortisol production in vitro, however, the effect of guanosine triphosphate (GTP) on cortisol production is not known. We studied the effect of GTP on cortisol production and investigated the regulation of in... |
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Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs.
J. Vet. Intern. Med. 26(4) , 1078-80, (2012) Trilostane is commonly used in the treatment of dogs with naturally occurring pituitary-dependent hyperadrenocorticism (PDH). Dose recommendations have varied from the manufacturer and the literature.As body weight increases, dose/kg or dosage/day of trilosta... |
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Prochloraz-induced oocyte maturation in rainbow trout (Oncorhynchus mykiss), a molecular and functional analysis.
Toxicol. Sci. 118(1) , 61-70, (2010) In the present study, we aimed at characterizing the effect of prochloraz, an imidazole fungicide, on the oocyte meiotic maturation process in a freshwater teleost species, the rainbow trout (Oncorhynchus mykiss). Full-grown post-vitellogenic ovarian follicle... |
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Temporal evaluation of effects of a model 3β-hydroxysteroid dehydrogenase inhibitor on endocrine function in the fathead minnow.
Environ. Toxicol. Chem. 30(9) , 2094-102, (2011) Inhibition of enzymes involved in the synthesis of sex steroids can substantially impact developmental and reproductive processes controlled by the hypothalmic-pituitary-gonadal (HPG) axis. A key steroidogenic enzyme that has received little attention from a ... |
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Aldosterone, hypertension and heart failure: insights from clinical trials.
Hypertens. Res. 33(9) , 872-5, (2010) Two clinical trials will be reviewed, RALES(1) and ILLUMINATE.(2) In RALES, low-dose spironolactone in addition to standard of care, produced a 30% improvement in survival in progressive heart failure, commonly assumed to reflect deleterious effects of aldost... |
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Evaluation of the use of baseline cortisol concentration as a monitoring tool for dogs receiving trilostane as a treatment for hyperadrenocorticism.
J. Am. Vet. Med. Assoc. 237(7) , 801-5, (2010) To determine whether a single measurement of cortisol concentration can be used to monitor dogs receiving trilostane for hyperadrenocorticism.Controlled drug efficacy trial.103 client-owned dogs.Results of ACTH stimulation tests before and during trilostane t... |
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Effects of fibroblast growth factor 9 (FGF9) on steroidogenesis and gene expression and control of FGF9 mRNA in bovine granulosa cells.
Endocrinology 153(9) , 4491-501, (2012) Gene expression of fibroblast growth factor-9 (FGF9) is decreased in granulosa cells (GC) of cystic follicles compared with normal dominant follicles in cattle. The objectives of this study were to investigate the effects of FGF9 on GC steroidogenesis, gene e... |
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Transcriptional regulatory dynamics of the hypothalamic-pituitary-gonadal axis and its peripheral pathways as impacted by the 3-beta HSD inhibitor trilostane in zebrafish (Danio rerio).
Ecotoxicol. Environ. Saf. 74(6) , 1461-70, (2011) To study mechanisms underlying generalized effects of 3β hydroxysteroid dehydrogenase (HSD3B) inhibition, reproductively mature zebrafish (Danio rerio) were exposed to trilostane at two dosages for 24, 48, or 96 h and their gonadal RNA samples profiled with A... |
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Effects of nonylphenol on aldosterone release from rat zona glomerulosa cells.
Chem. Biol. Interact. 195(1) , 11-7, (2012) Alkylphenol ethoxylate, which consists of approximately 80% nonylphenol ethoxylate (NPE), is a major nonionic surfactant. Nonylphenol (NP), the primary degradation product of NPE, has been reported to interfere with reproduction in fish, reptiles, and mammals... |