Pristimerin
Pristimerin structure
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Common Name | Pristimerin | ||
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| CAS Number | 1258-84-0 | Molecular Weight | 464.636 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 607.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C30H40O4 | Melting Point | 219.5°C | |
| MSDS | Chinese USA | Flash Point | 195.1±25.0 °C | |
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Pristimerin, a naturally occurring triterpenoid, protects against autoimmune arthritis by modulating the cellular and soluble immune mediators of inflammation and tissue damage.
Clin. Immunol. 155(2) , 220-30, (2014) Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting the synovial joints. The currently available drugs for RA are effective only in a proportion of patients and their prolonged use is associated with severe adverse effects. Thus, new anti-art... |
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Targeting tumor proteasome with traditional Chinese medicine.
Curr. Drug Discov. Technol. 7(1) , 46-53, (2010) The proteasome is a multicatalytic protease complex whose activity is required for the growth of normal or tumor cells. It has been shown that human cancer cells are more sensitive to proteasome inhibition than normal cells, indicating that the proteasome cou... |
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Biomimetic synthesis of xuxuarines Ealpha and Ebeta: structure revision of Rzedowskia bistriterpenoids.
Bioorg. Med. Chem. 16(4) , 1884-9, (2008) Reaction of pristimerin with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) resulted in a biomimetic-type coupling leading to xuxuarines Ealpha and Ebeta and not the previously reported Rzedowskia bistriterpenoids I and II suggesting that the structures prop... |
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[In vitro activity of the pristinamycin against the isolated staphylococci in the french hospitals in 1999-2000].
Pathol. Biol. 51(7) , 400-4, (2003) One thousand six hundred and fifty clinically significant, consecutive and non redundant strains of staphylococci, including 863 Staphylococcus aureus and 787 coagulase negative staphylococci (CNS), were isolated between October 1999 and March 2000 in 35 Fren... |
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Pristimerin inhibits breast cancer cell migration by up- regulating regulator of G protein signaling 4 expression.
Asian Pac. J. Cancer Prev. 13(4) , 1097-104, (2012) Pristimerin isolated from Celastrus and Maytenus spp can inhibit proteasome activity. However, whether pristimerin can modulate cancer metastasis is unknown.The impacts of pristimerin on the purified and intracellular chymotrypsin proteasomal activity, the le... |
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Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.
Blood 113(17) , 4027-37, (2009) As multiple myeloma tumors universally dysregulate cyclin D genes we conducted high-throughput chemical library screens for compounds that induce suppression of cyclin D2 promoter transcription. The top-ranked compound was a natural triterpenoid, pristimerin.... |
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Anticytomegalovirus activity of pristimerin, a triterpenoid quinone methide isolated from Maytenus heterophylla (Eckl. & Zeyh.).
Antivir. Chem. Chemother. 18(3) , 133-9, (2007) We examined the anticytomegalovirus properties of four compounds: pristimerin, the pristimerin analogue, lupeol and 2-acetylphenol-1-beta-D-glucopyranosyl (1 --> 6)-beta-D-xylpyranoside (acetophenol glycoside), isolated from Maytenus heterophylla, a Kenyan me... |
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Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells.
Mol. Pharmacol. 76(4) , 734-44, (2009) Naturally occurring triterpenoid compounds have long been used as anti-inflammatory, antimalarial, and insecticidal agents. It has become evident that some of the natural or synthetic triterpenoids have promising clinical potential as both a therapeutic and c... |
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Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria.
Mol. Cancer Ther. 4(8) , 1277-85, (2005) Pristimerin, a naturally occurring triterpenoid, has been shown to cause cytotoxicity in several cancer cell lines. However, the mechanism for the cytotoxic effect of pristimerin was never explored. In the present study, human breast cancer MDA-MB-231 cells t... |
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Antifungal properties of pristimerin and celastrol isolated from Celastrus hypoleucus.
Pest Manag. Sci. 61(1) , 85-90, (2005) Pristimerin and celastrol isolated from the roots of Celastrus hypoleucus (Oliv) Warb f argutior Loes exhibited inhibitory effects against diverse phytopathogenic fungi. Pristimerin and celastrol were found to inhibit the mycelial growth of Rhizoctonia solani... |