Epiandrosterone
Epiandrosterone structure
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Common Name | Epiandrosterone | ||
|---|---|---|---|---|
| CAS Number | 481-29-8 | Molecular Weight | 290.440 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 413.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H30O2 | Melting Point | 172-174 °C | |
| MSDS | USA | Flash Point | 176.4±21.3 °C | |
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Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.
J. Med. Chem. 51 , 1831-41, (2008) TGR5, a metabotropic receptor that is G-protein-coupled to the induction of adenylate cyclase, has been recognized as the molecular link connecting bile acids to the control of energy and glucose homeostasis. With the aim of disclosing novel selective modulat... |
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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
J. Med. Chem. 52 , 7488-502, (2009) 17beta-Hydroxysteroid dehydrogenase type 7 (17beta-HSD7) catalyzes the reduction of estrone (E(1)) into estradiol (E(2)) and of dihydrotestosterone (DHT) into 5alpha-androstane-3beta,17beta-diol (3beta-diol), therefore modulating the level of mitogenic estrog... |
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A simple method for the small scale synthesis and solid-phase extraction purification of steroid sulfates.
Steroids 92 , 74-80, (2014) Steroid sulfates are a major class of steroid metabolite that are of growing importance in fields such as anti-doping analysis, the detection of residues in agricultural produce or medicine. Despite this, many steroid sulfate reference materials may have limi... |
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Testicular synthesis and vitamin D action.
J. Clin. Endocrinol. Metab. 99(10) , 3766-73, (2014) The vitamin D system has pleiotropic effects not only in bone metabolism. Its role in testicular steroidogenesis is new and deserves intensive research.We hypothesize that vitamin D, especially 1,25 dihydroxyvitamin D3 [1,25(OH)2D3 (calcitriol)] induces male ... |
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16-bromoepiandrosterone, an activator of the mammalian immune system, inhibits glucose 6-phosphate dehydrogenase from Trypanosoma cruzi and is toxic to these parasites grown in culture.
Bioorg. Med. Chem. 18 , 4762-8, (2010) Glucose 6-phosphate dehydrogenase (G6PDH) catalyzes the first step of the pentose-phosphate pathway which supplies cells with ribose 5-phosphate (R5P) and NADPH. R5P is the precursor for the biosynthesis of nucleotides while NADPH is the cofactor of several d... |
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Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites.
Bioorg. Med. Chem. 17 , 2483-9, (2009) Dehydroepiandrosterone (DHEA) is known as an intermediate in the synthesis of mammalian steroids and a potent uncompetitive inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH), but not the enzyme from plants and lower eukaryotes. G6PDH catalyzes ... |