Caroverine HCl
Caroverine HCl structure
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Common Name | Caroverine HCl | ||
|---|---|---|---|---|
| CAS Number | 55750-05-5 | Molecular Weight | 401.93000 | |
| Density | 1.11g/cm3 | Boiling Point | 521.2ºC at 760mmHg | |
| Molecular Formula | C22H28ClN3O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 269ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Possible contribution of pannexin channel to ATP-induced currents in vitro in vasopressin neurons isolated from the rat supraoptic nucleus
Brain Res. 1394 , 71-8, (2011) Release of arginine vasopressin (AVP) from magnocellular neurosecretory cells (MNCs) of the supraoptic nucleus (SON) is controlled by the electrical activity of these neurons. ATP plays a crucial role in the regulation of SON MNCs by activating the purinergic... |
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[Drug therapy for disturbances of smelling].
Laryngorhinootologie. 83(2) , 124-34, (2004) Disorders of the sense of smell are frequent. This severely can affect the quality of live. Appropriate testing is needed to determine the nature of the patient's complaints. Following the pathogenesis, two main groups of smell disorders are discernable: The ... |
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[Therapy of olfactory loss].
Laryngorhinootologie. 82(8) , 552-4, (2003) Apart from olfactory loss due to sino-nasal disease therapy of olfactory dysfunction is a difficult task.Own investigations were carried out using alpha-lipoic acid (Hummel et al. 2002) and caroverine (Quint et al. 2002) in both patients with posttraumatic ol... |
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Caroverine, a multifunctional drug with antioxidant functions.
Biofactors 19(1-2) , 79-85, (2003) Here we show that lipid peroxidation of liposomal membranes was suppressed in the presence of Caroverine, a spasmolytic drug used in some countries. In order to understand the mechanism of this antioxidant action of Caroverine we studied the interaction of Ca... |
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Caroverine inhibits the conditioned place aversion induced by naloxone-precipitated morphine withdrawal in rats.
Neurosci. Lett. 349(2) , 91-4, (2003) Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. The present study examines the effect of caroverine in a craving model, ... |
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Caroverine in tinnitus treatment.
Acta Otolaryngol. 118(4) , 606-8, (1998)
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Different action of memantine and caroverine on glutamatergic transmission in the mammalian cochlea.
Adv. Otorhinolaryngol. 59 , 18-25, (2002) Glutamate is the major transmitter candidate between inner hair cells and the afferent neurons of the mammalian cochlea. We investigated the action of memantine (1-amino-3,5-dimethyl-adamantane) and the quinoxaline derivative caroverine [1-diethylaminoethyl-3... |
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Clinical experience with caroverine in inner ear diseases.
Adv. Otorhinolaryngol. 59 , 156-62, (2002) The glutamatergic synapses between the cochlear inner hair cells and their afferent neurons seem to be mostly involved in the pathophysiology of the cochlea. Glutamatergic neurotoxicity is characterized by a mitochondrial overproduction of free oxygen radical... |
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Does a glutamate receptor blocker (Caroverine) enhance haloperidol in the treatment of schizophrenia?
Neuropsychobiology 40(3) , 140-1, (1999)
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Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs.
Audiol. Neurootol. 8(1) , 49-56, (2003) Caroverine, an N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, has been shown to protect the inner ear from excitotoxicity and to be effective in the treatment of cochlear synaptic tinnitus. Local adminis... |