10-HYDROXYWARFARIN
10-HYDROXYWARFARIN structure
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Common Name | 10-HYDROXYWARFARIN | ||
|---|---|---|---|---|
| CAS Number | 83219-99-2 | Molecular Weight | 324.32700 | |
| Density | 1.388 g/cm3 | Boiling Point | 509.2ºC at 760 mmHg | |
| Molecular Formula | C19H16O5 | Melting Point | 183-185ºC | |
| MSDS | Chinese USA | Flash Point | 185ºC | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.
J. Chromatogr. A. 1363 , 200-6, (2014) Several offline and online 2D HPLC methods were investigated for the reversed phase resolution of a complex mixture of closely related warfarin and hydroxywarfarin isomers. By combining reversed phase achiral/chiral HPLC separation with UV-triggered fraction ... |
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Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.
Chem. Res. Toxicol. 23(5) , 939-45, (2010) Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how metabolic capacity is influenced among patients. Cytochrome P45... |
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Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.
Drug Metab. Lett. 4(4) , 213-9, (2010) Effective coumadin (R/S-warfarin) therapy is complicated by inter-individual variability in metabolism. Recent studies have demonstrated that CYP3A isoforms likely contribute to patient responses and clinical outcomes. Despite a significant focus on CYP3A4, l... |
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In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin.
Drug Metab. Dispos. 29(6) , 877-86, (2001) It has been demonstrated that the activity of cytochrome P450 (CYP)3A4 in certain cases is stimulated by quinidine (positive heterotropic cooperativity). We report herein that the 4'- and 10-hydroxylation of S- and R-warfarin are enhanced in human liver micro... |
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Warfarin is an effective modifier of multiple UDP-glucuronosyltransferase enzymes: evaluation of its potential to alter the pharmacokinetics of zidovudine.
J. Pharm. Sci. 104(1) , 244-56, (2014) In this study, we aimed to determine the modulatory effects of warfarin (an extensively used anticoagulant drug) and its metabolites on UDP-glucuronosyltransferase (UGT) activity and to assess the potential of warfarin to alter the pharmacokinetics of zidovud... |
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Determination of warfarin enantiomers and hydroxylated metabolites in human blood plasma by liquid chromatography with achiral and chiral separation.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 818(2) , 191-8, (2005) An assay comprising two simple, selective and isocratic HPLC methods with UV detection was developed and validated for measuring warfarin enantiomers and all five warfarin monohydroxylated metabolites in patient blood plasma. Following liquid/liquid extractio... |
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Effect of particle size on the speed and resolution of chiral separations using supercritical fluid chromatography.
J. Chromatogr. A. 1363 , 250-6, (2014) Fast chiral supercritical fluid chromatography (SFC) separations have become important due to the increasing use of high-throughput experimentation (HTE) in organic synthesis. These HTE experiments can generate hundreds of samples for chiral analysis that nee... |
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Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(15-16) , 1056-62, (2011) Coumadin (R/S-warfarin) is a commonly prescribed anticoagulant for over ∼20 million Americans. Although highly efficacious, positive clinical outcomes during warfarin therapy depend on maintaining a narrow therapeutic range for the drug. This goal is challeng... |
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Kinetic study of cytochrome P450 3A4 activity on warfarin by capillary electrophoresis with fluorescence detection.
J. Chromatogr. A. 1082(2) , 235-9, (2005) The use of capillary electrophoresis (CE) for the determination of cytochrome P450 3A4 (CYP3A4) activity with R-warfarin as a substrate was investigated. CYP3A4 activity was determined by the quantitation of the product, 10-hydroxywarfarin, based on separatio... |
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The influence of co-treatment with carbamazepine, amiodarone and statins on warfarin metabolism and maintenance dose.
Eur. J. Clin. Pharmacol. 62(4) , 291-6, (2006) Warfarin is a frequently used anticoagulant drug with narrow therapeutic index and high interindividual variability in the dose requirement. We have previously shown that warfarin dose is influenced by cytochrome P450 (CYP) 2C9 genotype, age, body weight and ... |