Moxidectin
Moxidectin structure
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Common Name | Moxidectin | ||
|---|---|---|---|---|
| CAS Number | 113507-06-5 | Molecular Weight | 639.819 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 790.0±70.0 °C at 760 mmHg | |
| Molecular Formula | C37H53NO8 | Melting Point | 132 °C | |
| MSDS | Chinese USA | Flash Point | 431.6±35.7 °C | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
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Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: "The Worminator".
Int. J. Parasitol. Drugs Drug Resist. 4(3) , 233-43, (2014) A major hindrance to evaluating nematode populations for anthelmintic resistance, as well as for screening existing drugs, new compounds, or bioactive plant extracts for anthelmintic properties, is the lack of an efficient, objective, and reproducible in vitr... |
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In-vitro activity of avermectins against Mycobacterium ulcerans.
PLoS Negl. Trop. Dis. 9(3) , e0003549, (2015) Mycobacterium ulcerans causes Buruli ulcer (BU), a debilitating infection of subcutaneous tissue. There is a WHO-recommended antibiotic treatment requiring an 8-week course of streptomycin and rifampicin. This regime has revolutionized the treatment of BU but... |
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The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.
EMBO Mol. Med. 6(10) , 1263-78, (2014) Constitutive activation of canonical WNT-TCF signaling is implicated in multiple diseases, including intestine and lung cancers, but there are no WNT-TCF antagonists in clinical use. We have performed a repositioning screen for WNT-TCF response blockers aimin... |
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Effects of macrocyclic lactones on the reproductive parameters of engorged Rhipicephalus (Boophilus) microplus females detached from experimentally infested cattle.
Exp. Parasitol. 135(1) , 72-8, (2013) The present study therefore assessed the deleterious effects of MLs (ivermectin, abamectin, doramectin and moxidectin) on the reproductive parameters of engorged Rhipicephalus (Boophilus) microplus females that naturally detached from experimentally infested ... |
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Moxidectin causes adult worm mortality of human lymphatic filarial parasite Brugia malayi in rodent models.
Folia Parasitol (Praha) 61(6) , 561-70, (2014) Moxidectin is a macrocyclic lactone belonging to milbemycin family closely related to ivermectin and is currently progressing towards Phase III clinical trial against human infection with the filaria Onchocerca volvulus (Leuckart, 1894). There is a single rep... |
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Multiple anthelmintic resistance of Haemonchus contortus, including a case of moxidectin resistance, in a Dutch sheep flock.
Vet. Rec. 173(22) , 552, (2013)
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Extralabel use of ivermectin and moxidectin in food animals.
J. Am. Vet. Med. Assoc. 217(5) , 668-71, (2000)
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Analytical profile of moxidectin.
Profiles Drug Subst. Excip. Relat. Methodol. 38 , 315-66, (2013) Moxidectin or F28249α is a potent endectocide and semisynthetic methoxime derivative of naturally occurring nemadectin. It is well known for the novel mode of action against a broad range of nematode and anthropod animal parasites. In this work, physicochemic... |