Chloromethyl chloroformate
Chloromethyl chloroformate structure
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Common Name | Chloromethyl chloroformate | ||
|---|---|---|---|---|
| CAS Number | 22128-62-7 | Molecular Weight | 128.942 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 107.9±13.0 °C at 760 mmHg | |
| Molecular Formula | C2H2Cl2O2 | Melting Point | <-20ºC | |
| MSDS | Chinese USA | Flash Point | 25.5±15.2 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes.
Bioorg. Med. Chem. 8(7) , 1719-25, (2000) A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic ac... |
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Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media.
Arch. Pharm. (Weinheim) 340(1) , 32-40, (2007) Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters o... |
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Water soluble cyclosporine monomethoxy poly(ethyleneglycol) conjugates as potential prodrugs.
Arch. Pharm. Res. 27(6) , 662-9, (2004) The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroform... |