Oridonin
Oridonin structure
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Common Name | Oridonin | ||
|---|---|---|---|---|
| CAS Number | 28957-04-2 | Molecular Weight | 364.433 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 599.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H28O6 | Melting Point | 248-250ºC | |
| MSDS | Chinese USA | Flash Point | 215.0±23.6 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].
Sichuan Da Xue Xue Bao. Yi Xue Ban 43(3) , 362-6, (2012) To study the anti-tumor effect of tanshinon II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines SUP-B15, K562, CEM, HL-60 and NB4.To study the anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, The leukemia c... |
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Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.
Pharmazie 69(7) , 532-6, (2014) The pregnane X receptor (PXR) is a key regulator of CYP3A4, which is involved in catalyzing the metabolic conversion of a number of endogenous substrates. In this study, we screened 22 compounds isolated from traditional Chinese herbal medicines using lucifer... |
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The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells.
J. Gastroenterol. 48(2) , 182-92, (2013) Fatty acid synthase (FAS) inhibitors could be a therapeutic target in cancer treatment. However, only a few FAS inhibitors showing clinical potential have been reported. Oridonin is a diterpenoid isolated from Rabdosia rubescens. Although it has antiprolifera... |
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Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-κB-COX-2-IL-1β pathway.
Free Radic. Res. 46(10) , 1207-19, (2012) We previously demonstrated that oridonin-induced autophagy enhanced efferocytosis (phagocytosis of apoptotic cells) by macrophage-like U937 cells through activation of the inflammatory pathways. In this study, exposure of U937 cells to 2.5 μM oridonin caused ... |
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Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway.
Int. J. Oncol. 41(3) , 949-58, (2012) Gemcitabine is currently the best treatment available for pancreatic cancer (PaCa); however, patients with the disease develop resistance to the drug over time. Agents that can either enhance the effects of gemcitabine or overcome chemoresistance to the drug ... |
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Reactive oxygen species H2O2 and •OH, but not O2•(-) promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells.
Int. Immunopharmacol. 15(2) , 414-23, (2013) We reported previously that phagocytosis of apoptotic cells by U937 cells was enhanced by the treatment with oridonin that showed high activity to induce the generation of reactive oxygen species (ROS) in many cells. ROS, important signaling molecules, are in... |
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Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents.
Molecules 17(6) , 7556-68, (2012) To search for novel nitric oxide (NO) releasing anti-tumor agents, a series of novel furoxan/oridonin hybrids were designed and synthesized. Firstly, the nitrate/nitrite levels in the cell lysates were tested by a Griess assay and the results showed that thes... |
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Hydroxyl radical (·OH) played a pivotal role in oridonin-induced apoptosis and autophagy in human epidermoid carcinoma A431 cells.
Biol. Pharm. Bull. 35(12) , 2148-59, (2012) Oridonin, a diterpenoid compound extracted and purified from Rabdosia rubescen, has been reported to induce tumor cell apoptosis through tyrosine kinase pathway. To further examine the mechanism of oridonin, we selected human epidermoid carcinoma A431 cell as... |
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Interruption of hepatocyte growth factor signaling augmented oridonin-induced death in human non-small cell lung cancer A549 cells via c-met-nuclear factor-κB-cyclooxygenase-2 and c-Met-Bcl-2-caspase-3 pathways.
Biol. Pharm. Bull. 35(7) , 1150-8, (2012) The aim of this study was to elucidate the molecular mechanisms mediating hepatocyte growth factor (HGF)-induced protection against oridonin-induced apoptosis in A549 cells. Oridonin induced decrease in Bcl-2/Bax ratio and activation of caspase-3, while these... |
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Oridonin: targeting programmed cell death pathways as an anti-tumour agent.
Cell Prolif. 45(6) , 499-507, (2012) Oridonin, an active diterpenoid isolated from traditional Chinese herbal medicine, has drawn rising attention for its remarkable apoptosis- and autophagy-inducing activity and relevant molecular mechanisms in cancer therapy. Apoptosis is a well known type of ... |