Nodularin
Nodularin structure
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Common Name | Nodularin | ||
|---|---|---|---|---|
| CAS Number | 118399-22-7 | Molecular Weight | 824.963 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C41H60N8O10 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 11℃ | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Biological treatment options for cyanobacteria metabolite removal--a review.
Water Res. 46(5) , 1536-48, (2012) The treatment of cyanobacterial metabolites can consume many resources for water authorities which can be problematic especially with the recent shift away from chemical- and energy-intensive processes towards carbon and climate neutrality. In recent times, t... |
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Simultaneous detection of nine cyanotoxins in drinking water using dual solid-phase extraction and liquid chromatography-mass spectrometry.
Toxicon 58(2) , 209-18, (2011) A solid-phase extraction (SPE)-liquid chromatography (LC)-mass spectrometry (MS) method was developed to concentrate and detect nine cyanotoxins simultaneously, including six microcystins (MCs) congeners, nodularin (NOD), anatoxin-a (ATX) and cylindrospermops... |
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Tumor promoters--microcystin-LR, nodularin and TNF-α and human cancer development.
Anticancer Agents Med. Chem. 11(1) , 4-18, (2011) Microcystin-LR and nodularin, along with okadaic acid, are potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A). The mechanisms of action of microcystin-LR and nodularin in the liver and that of okadaic acid, a potent tumor promoter on mouse skin... |
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Complexation of microcystins and nodularin by cyclodextrins in aqueous solution, a potential removal strategy.
Environ. Sci. Technol. 45(6) , 2293-300, (2011) Cyanotoxins are potent toxic compounds produced by cyanobacteria during algal blooms, which threaten drinking water supplies. These compounds can poison and kill animals and humans. The host-guest interactions of α-, β-, and γ-cyclodextrins (CD) with problema... |
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Simultaneous quantification of microcystins and nodularin in aerosol samples using high-performance liquid chromatography/negative electrospray ionization tandem mass spectrometry.
Rapid Commun. Mass Spectrom. 26(12) , 1497-506, (2012) Cyanobacteria are a small group of photosynthetic planktonic bacteria, producing a large group of strong hepatotoxins called microcystins (MCs). Many studies have been conducted to evaluate the presence of MCs and nodularin (NOD) in water or in marine organis... |
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Differentiation of microcystin, nodularin, and their component amino acids by drop-coating deposition Raman spectroscopy.
Anal. Chem. 83(24) , 9273-80, (2011) Raman spectra of microcystin-LR (MC-LR), MC-RR, MC-LA, MC-LF, MC-LY, MC-LW, MC-YR, and nodularin collected by drop-coating deposition Raman (DCDR) spectroscopy are sufficiently unique for variant identification. Amino acid spectra of L-phenylalanine, L-leucin... |
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Lymphoid depletion in two dogs with nodularin intoxication.
Vet. Rec. 169(1) , 15, (2011)
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Induction of Fas receptor and Fas ligand by nodularin is mediated by NF-κB in HepG2 cells.
Toxicol. Appl. Pharmacol. 251(3) , 245-52, (2011) Nodularin is a natural toxin with multiple features, including inhibitor of protein phosphatases 1 and 2A as well as tumor initiator and promoter. One unique feature of nodularin is that this chemical is a hepatotoxin. It can accumulate into the liver after c... |
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Nodularin exposure induces SOD1 phosphorylation and disrupts SOD1 co-localization with actin filaments.
Toxins (Basel.) 4(12) , 1482-99, (2012) Apoptotic cell death is induced in primary hepatocytes by the Ser/Thr protein phosphatase inhibiting cyanobacterial toxin nodularin after only minutes of exposure. Nodularin-induced apoptosis involves a rapid development of reactive oxygen species (ROS), whic... |
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Quantitative assessment of aerosolized cyanobacterial toxins at two New Zealand lakes.
J. Environ. Monit. 13(6) , 1617-24, (2011) The cyanobacterial toxins, nodularin and microcystin, are highly efficient inhibitors of cellular protein phosphatases. Toxicity primarily evolves following ingestion of cyanobacterial material or toxins and results in liver and renal pathology. Ingestion is ... |