Phytosphingosine
Phytosphingosine structure
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Common Name | Phytosphingosine | ||
|---|---|---|---|---|
| CAS Number | 554-62-1 | Molecular Weight | 317.507 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 483.7±40.0 °C at 760 mmHg | |
| Molecular Formula | C18H39NO3 | Melting Point | 102ºC | |
| MSDS | USA | Flash Point | 246.4±27.3 °C | |
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14-3-3-regulated Ca(2+)-dependent protein kinase CPK3 is required for sphingolipid-induced cell death in Arabidopsis.
Cell Death Differ. 20(2) , 209-17, (2013) In eukaryotic cells, sphingoid long chain bases (LCBs) such as sphingosine or phytosphingosine (PHS) behave as second messengers involved in various processes including programmed cell death (PCD). In plants, induction of PCD by LCBs has now been described, b... |
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Detection of water-soluble disease-associated PrP species in blood and brain of scrapie-infected hamster.
Arch. Virol. 160 , 2219-29, (2015) The high-speed supernatant (S(HS)) of scrapie-infected hamster brain homogenate contains a soluble infectivity similar to that of the plasma that escapes leukodepletion and can transmit prion infection. This recent finding highlights the fact that soluble pri... |
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Morphogenesis checkpoint kinase Swe1 is the executor of lipolysis-dependent cell-cycle progression.
Proc. Natl. Acad. Sci. U. S. A. 112(10) , E1077-85, (2015) Cell growth and division requires the precise duplication of cellular DNA content but also of membranes and organelles. Knowledge about the cell-cycle-dependent regulation of membrane and storage lipid homeostasis is only rudimentary. Previous work from our l... |
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B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3.
Oncotarget 6 , 11378-94, (2015) The molecular interactions between B-cell precursor acute lymphoblastic leukemia (pre-B ALL) cells and stromal cells in the bone marrow that provide microenvironmentally-mediated protection against therapeutic drugs are not well-defined. Galectin-3 (Lgals3) i... |
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Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency.
Hum. Mol. Genet. 24 , 3238-47, (2015) Acyl-CoA dehydrogenase 9 (ACAD9) is an assembly factor for mitochondrial respiratory chain Complex I (CI), and ACAD9 mutations are recognized as a frequent cause of CI deficiency. ACAD9 also retains enzyme ACAD activity for long-chain fatty acids in vitro, bu... |
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Phytosphingosine derivatives ameliorate skin inflammation by inhibiting NF-κB and JAK/STAT signaling in keratinocytes and mice.
J. Invest. Dermatol. 134(4) , 1023-32, (2014) Phytosphingosine is abundant in plants and fungi and is found in mammalian epidermis, including the stratum corneum. Phytosphingosine and its derivatives N-acetyl phytosphingosine and tetraacetyl phytosphingosine are part of the natural defense system of the ... |
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Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease.
PLoS ONE 6(1) , e15946, (2011) We identified three S. cerevisiae lipid elongase null mutants (elo1Δ, elo2Δ, and elo3Δ) that enhance the toxicity of alpha-synuclein (α-syn). These elongases function in the endoplasmic reticulum (ER) to catalyze the elongation of medium chain fatty acids to ... |
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Phenotypic and functional activation of hyporesponsive KIRnegNKG2Aneg human NK-cell precursors requires IL12p70 provided by Poly(I:C)-matured monocyte-derived dendritic cells.
Cancer. Immunol. Res. 2(10) , 1000-10, (2014) A functionally responsive natural killer (NK)-cell repertoire requires the acquisition of inhibitory NKG2A and killer immunoglobulin-like receptors (KIR) through pathways that remain undefined. Functional donor NK cells expressing KIRs for non-self class I MH... |
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Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair.
J. Orthop. Res. 33(1) , 17-24, (2014) Parathyroid hormone (PTH) 1-34 is known to enhance fracture healing. Tendon repair is analogous to bone healing in its dependence on the proliferation and differentiation of mesenchymal stem cells, matrix formation, and tissue remodeling.(1,2,3) We hypothesiz... |
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Differential increases of specific FMR1 mRNA isoforms in premutation carriers.
J. Med. Genet. 52(1) , 42-52, (2014) Over 40% of male and ∼16% of female carriers of a premutation FMR1 allele (55-200 CGG repeats) will develop fragile X-associated tremor/ataxia syndrome, an adult onset neurodegenerative disorder, while about 20% of female carriers will develop fragile X-assoc... |