Benzbromarone
Benzbromarone structure
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Common Name | Benzbromarone | ||
|---|---|---|---|---|
| CAS Number | 3562-84-3 | Molecular Weight | 424.083 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 514.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H12Br2O3 | Melting Point | 161 - 163ºC | |
| MSDS | Chinese USA | Flash Point | 264.7±30.1 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.
Nephrology (Carlton.) 16(2) , 156-62, (2011) Hyperuricaemia is a significant factor in a variety of diseases, including gout and cardiovascular diseases. The kidney plays a dominant role in maintaining plasma urate levels through the excretion process. Human renal urate transporter URAT1 is thought to b... |
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The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.
Oncogene 34(14) , 1799-810, (2015) Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent studies reveal that p53 has significant roles in cellular m... |
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[Clinical strategies for prevention of drug-induced urinary calculi].
Clin. Calcium 21(10) , 1457-63, (2011) Drug-induced urinary calculi, although they account for only 1-2% of urinary calculi, deserve consideration because most of them are preventable. In the drug-containing calculi resulting from the crystallization of a certain drug and its metabolites in the ur... |
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Direct radical scavenging activity of benzbromarone provides beneficial antioxidant properties for hyperuricemia treatment.
Biol. Pharm. Bull. 38(3) , 487-92, (2015) Uric acid exerts an important antioxidant effect against external oxidative stress under physiological conditions. However, uric acid itself can increase oxidative stress via reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation in ad... |
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Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein e-deficient mice.
Biol. Pharm. Bull. 37(12) , 1866-71, (2014) Although hyperlipidemia, high blood pressure, and diabetes increase the risk of arteriosclerosis, it is not clear whether hyperuricemia increases the risk of arteriosclerosis or not. We examined the effects of uric acid and curative drugs for hyperuricemia on... |
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Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MS(E) data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates.
Rapid Commun. Mass Spectrom. 28(24) , 2695-703, (2014) Analytical methods to assess glutathione (GSH) conjugate formation based on mass spectrometry usually take advantage of the specific fragmentation behavior of the glutathione moiety. However, most methods used for GSH adduct screening monitor only one specifi... |
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Anti-inflammatory and immunomodulatory effects of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats.
Life Sci. 91(11-12) , 369-76, (2012) Uric acid nephropathy (UAN) is due to excessive uric acid, which leads to hyperuricemia and kidney damage via the deposition of urate microcrystals in the kidneys. Iridoid glycosides of Paederia scandens (IGPS) is a major active component isolated from the tr... |
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Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies.
Drug Des. Devel. Ther. 6 , 323-39, (2012) Human uric acid transporter 1 (hURAT1; SLC22A12) is a very important urate anion exchanger. Elevated urate levels are known to play a pivotal role in cardiovascular diseases, chronic renal disease, diabetes, and hypertension. Therefore, the development of pot... |
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Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure.
Toxicology 324 , 136-46, (2014) Benzbromarone is an uricosuric structurally related to amiodarone and a known mitochondrial toxicant. The aim of the current study was to improve our understanding in the molecular mechanisms of benzbromarone-associated hepatic mitochondrial toxicity. In HepG... |
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Resolution of massive tophaceous gout with three urate-lowering drugs.
Am. J. Med. 126(11) , e9-10, (2013)
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