2-Methylthioethyl chloride
2-Methylthioethyl chloride structure
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Common Name | 2-Methylthioethyl chloride | ||
|---|---|---|---|---|
| CAS Number | 542-81-4 | Molecular Weight | 110.606 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 140.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C3H7ClS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 42.2±0.0 °C | |
| Symbol |
GHS02, GHS05, GHS06, GHS08 |
Signal Word | Danger | |
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2,6-Dithiopurine blocks toxicity and mutagenesis in human skin cells exposed to sulfur mustard analogues, 2-chloroethyl ethyl sulfide and 2-chloroethyl methyl sulfide.
Chem. Res. Toxicol. 23(3) , 497-503, (2010) Sulfur mustard (bis-(2-chloroethyl)sulfide) is a well-known chemical warfare agent that induces debilitating cutaneous toxicity in exposed individuals. It is also known to be carcinogenic and mutagenic because of its ability to damage DNA via electrophilic at... |
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The more basic isoform of eEF1A relates to tumour cell phenotype and is modulated by hyper-proliferative/differentiating stimuli in normal lymphocytes and CCRF-CEM T-lymphoblasts.
Hematol. Oncol. 31(2) , 370-6, (2013) The elongation factor 1A proteins (eEF1A1/A2) are known to play a role in tumours. We previously found that a more basic isoform of eEF1A (MBI-eEF1A) is present in the cytoskeletal/nuclear-enriched extracts of CCRF-CEM T-lymphoblasts but not in those of norma... |
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Cutaneous toxicity of 2-chloroethyl methyl sulfide in isolated perfused porcine skin.
Toxicol. Appl. Pharmacol. 104(1) , 167-79, (1990) Previous research has shown the isolated perfused porcine skin flap (IPPSF) to be a novel in vitro experimental model for investigating xenobiotic percutaneous absorption. In this study, the IPPSF was used to biochemically and morphologically assess the derma... |
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Discriminant analysis indicates a single sperm protein (SP22) is predictive of fertility following exposure to epididymal toxicants.
J. Androl. 18(2) , 139-50, (1997) In a previous study, we found that ethane dimethanesulphonate (EDS) compromised the fertilizing ability of proximal cauda epididymal sperm from the rat within 4 days of exposure, an effect that persisted in castrated, testosterone (T)-implanted animals, estab... |
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Activation of H-ras oncogenes in male B6C3F1 mouse liver tumors induced by vinthionine or 2-chloroethyl-methyl sulfide.
Carcinogenesis 17(6) , 1361-4, (1996) Vinthionine (S-vinyl-DL-homocysteine) is hepatocarcinogenic in rats and mice. [Vinyl-14C]vinthionine binds covalently to rat liver DNA, RNA and protein in vivo, but not in vitro. This amino acid is directly mutagenic in Salmonella typhimurium TA100 and TA1535... |