benzethonium chloride
benzethonium chloride structure
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Common Name | benzethonium chloride | ||
|---|---|---|---|---|
| CAS Number | 121-54-0 | Molecular Weight | 448.081 | |
| Density | 0.998 g/mL at 20 °C | Boiling Point | N/A | |
| Molecular Formula | C27H42ClNO2 | Melting Point | 162-164 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05, GHS06, GHS09 |
Signal Word | Danger | |
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Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain.
J. Neuroinflammation 11 , 128, (2014) An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggested to be associated with the disorder. Munc18-overexpressin... |
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Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet.
Neurobiol. Dis. 73 , 307-18, (2014) Quality nutrition during the period of brain formation is a predictor of brain functional capacity and plasticity during adulthood; however it is not clear how this conferred plasticity imparts long-term neural resilience. Here we report that early exposure t... |
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Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus.
Antimicrob. Agents Chemother. 54 , 4107-11, (2010) Plasmids that carry the multidrug efflux genes qacA and qacB are widely distributed in methicillin-resistant Staphylococcus aureus (MRSA). Although the QacA and QacB proteins are similar to each other, their respective substrate specificities may differ. We i... |
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Acute otitis externa: an update.
Am. Fam. Physician 86(11) , 1055-61, (2012) Acute otitis externa is a common condition involving inflammation of the ear canal. The acute form is caused primarily by bacterial infection, with Pseudomonas aeruginosa and Staphylococcus aureus the most common pathogens. Acute otitis externa presents with ... |
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Bifidobacterium longum subsp. infantis BB-02 attenuates acute murine experimental model of inflammatory bowel disease.
Benef. Microbes 6 , 277-86, (2015) Inflammatory bowel diseases (IBD) are chronic inflammatory conditions, characterised by remissions and relapses episodes, whose main manifestations are ulcerative colitis and Crohn's disease. Ulcerative colitis (UC), one of the main forms of IBD, has as stand... |
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Memory deficit associated with increased brain proinflammatory cytokine levels and neurodegeneration in acute ischemic stroke.
Arq. Neuropsiquiatr. 73 , 655-9, (2015) The present study aimed to investigate behavioral changes and neuroinflammatory process following left unilateral common carotid artery occlusion (UCCAO), a model of cerebral ischemia. Post-ischemic behavioral changes following 15 min UCCAO were recorded 24 h... |
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In ferrochelatase-deficient protoporphyria patients, ALAS2 expression is enhanced and erythrocytic protoporphyrin concentration correlates with iron availability.
Blood Cells Mol. Dis. 54(1) , 71-7, (2014) The activity of the erythroid-specific isoenzyme of 5-aminolevulinic acid synthase (ALAS2), the first and rate-limiting enzyme in heme biosynthesis, is down-regulated during iron-deficiency. Ferrochelatase (FECH), the last enzyme of this pathway, inserts iron... |
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Synthesis and antimycobacterial activities of non-purine analogs of 6-aryl-9-benzylpurines: Imidazopyridines, pyrrolopyridines, benzimidazoles, and indoles.
Bioorg. Med. Chem. 19 , 3483-91, (2011) 6,9-Disubstituted purines and 7-deazapurines are known to be powerful inhibitors of Mycobacterium tuberculosis (Mtb) in vitro. Analogs modified in the six-membered ring (imidazopyridines, pyrrolopyridines, benzimidazoles, and indoles) were synthesized and eva... |
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Magnetic "fishing" assay to screen small-molecule mixtures for modulators of protein-protein interactions.
Anal. Chem. 82(23) , 9850-7, (2010) Protein-protein interactions are an intricate part of biological pathways and have become important targets for drug discovery. Here we present a two-stage magnetic bead assay to functionally screen small-molecule mixtures for modulators of protein-based inte... |
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Stimulation of suicidal erythrocyte death by benzethonium.
Cell Physiol. Biochem. 28(2) , 347-54, (2011) Benzethonium, an antimicrobial surfactant widely used as preservative of pharmaceuticals, topical wound care product and oral disinfectant, triggers apoptosis of several cell types. The apoptosis is preceded and possibly triggered by mitochondrial depolarizat... |