glutethimide
glutethimide structure
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Common Name | glutethimide | ||
|---|---|---|---|---|
| CAS Number | 77-21-4 | Molecular Weight | 217.264 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 393.5±31.0 °C at 760 mmHg | |
| Molecular Formula | C13H15NO2 | Melting Point | 103 - 104ºC | |
| MSDS | N/A | Flash Point | 161.8±25.0 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Enantioselective separation of several piperidine-2, 6-diones on a covalently bonded cellulose 3,5-dimethylphenyl carbamate/10-undecenoate chiral selector.
Biomed. Chromatogr. 11(5) , 303-6, (1997) A series of piperidine-2, 6-dione drugs were enantiomerically resolved on a covalently bonded cellulose 3,5-dimethylphenyl carbamate/10-undecenoate chiral stationary phase (CSP), under normal- or reversed-phase conditions. A single column that can be applied ... |
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Influence of dexaminoglutethimide, an optical isomer of aminoglutethimide, on the disposition of estrone sulfate in postmenopausal breast cancer patients.
J. Clin. Endocrinol. Metab. 83(8) , 2687-93, (1998) Aminoglutethimide (AG) has been the most widely used aromatase inhibitor in breast cancer patients to date. Commercially, AG (Orimeten) is available as a racemate (DL-AG). Previous studies suggested the stereoisomers of AG (D-AG and L-AG) to differ considerab... |
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Automated screening platform with isochronal-parallel analysis and conditioning for rapid method development of chiral separations.
J. Sep. Sci. 30(9) , 1255-61, (2007) An automated chiral separation-screening platform was developed, allowing separation analysis on one column while another column is simultaneously equilibrated with a different mobile phase (MP). The platform can be set up from usual HPLC components at modera... |
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Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC).
Biochim. Biophys. Acta 1472(3) , 658-67, (1999) 5-Aminolevulinic acid synthase (ALA synthase), the rate-controlling enzyme of hepatic heme biosynthesis, is feed-back repressed by heme. In the liver, chemicals such as barbiturates markedly induce ALA synthase, especially in the presence of partial defects o... |
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The study of codeine-gluthetimide pharmacokinetic interaction in rats.
J. Pharm. Biomed. Anal. 32(4-5) , 867-77, (2003) A high-performance liquid chromatographic (HPLC) assay with native fluorescence detection was developed for the simultaneous quantification of codeine and its two metabolites, morphine and morphine-3-glucuronide (M-3-G), in rat plasma. Solid-phase extraction ... |
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Enantioseparation of glutethimide and its 5-OH-metabolite in capillary electrophoresis and study of selector-selectand interactions using one-dimensional rotating frame nuclear Overhauser and exchange spectroscopy.
Electrophoresis 23(12) , 1906-11, (2002) Enantioseparation of glutethimide (GT) and its 5-hydroxy metabolite (5-OH-GT) has been studied with several charged cyclodextrin (CD) derivatives. The emphasis was made on the enantiomer migration order of GT and simultaneous enantioseparation of GT and 5-OH-... |
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Influence of glutethimide on rat brain mononucleotides by sub-chronic codeine treatment.
J. Cell. Mol. Med. 5(4) , 409-16, (2001) It was investigated the in vivo effect of glutethimide on the intracellular neuroadaptation characteristic for m-opioid receptor tolerance induced by chronic codeine treatment and reflected by increased levels of adenylyl cyclase (AC) and cAMP-dependent prote... |
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Isolation of regioisomers of N-alkylprotoporphyrin IX from chick embryo liver after treatment with porphyrinogenic xenobiotics.
Can. J. Physiol. Pharmacol. 79(9) , 814-21, (2001) Several porphyrinogenic xenobiotics cause mechanism-based inactivation of cytochrome P450 (P450) isozymes with concomitant formation of a mixture of four N-alkylprotoporphyrin IX (N-alkylPP) regioisomers, which have ferrochelatase inhibitory properties. To is... |
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Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase.
Arch. Biochem. Biophys. 360(2) , 239-47, (1998) We had previously found that combined treatment with isopentanol and ethanol synergistically induced CYP2H protein and activity in cultured chick nepatoytes. Here we investigated the mechanism of induction of CYP2H by the alcohols and whether they caused a co... |
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A study of the effects of large doses of glutethimide that were used for self-poisoning during pregnancy on human fetuses.
Toxicol. Ind. Health 24(1-2) , 69-78, (2008) Animal investigations showed some embryolethal and teratogenic effects of glutethimide, a piperidindion derivative non-barbital hypnotic drug. Thus, the objective of this study was to evaluate the effects of very large doses of glutethimide that were used for... |