Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2
Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2 structure
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Common Name | Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2 | ||
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| CAS Number | 99566-27-5 | Molecular Weight | 1081.27 | |
| Density | 1.38 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C54H76N14O10 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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The anti-inflammatory potential of neuropeptide FF in vitro and in vivo.
Peptides 47 , 124-32, (2013) Neuropeptide FF (NPFF) has many functions in regulating various biological processes. However, little attention has been focused on the anti-inflammatory effect of this peptide. In the present study, the in vitro anti-inflammatory activity of NPFF in both pri... |
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Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test.
Peptides 30(9) , 1683-8, (2009) GPR103 is one of the orphan G protein-coupled receptors. Recently, an endogenous ligand for GPR103, 26RFa, was identified. Many 26RFa binding sites have been observed in various nuclei of the brain involved in the processing of pain such as the parafascicular... |
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Pressor and tachycardic responses to intrathecal administration of neuropeptide FF in anesthetized rats.
Peptides 31(4) , 683-8, (2010) Neuropeptide FF (NPFF) belongs to a neuropeptide family including two precursors (pro-NPFF(A) and pro-NPFF(B)) and two receptors (NPFF(1) and NPFF(2)). NPFF and NPFF receptor mRNAs have been reported to be highly expressed and localized in the rat and human s... |
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Nonpeptide ligands of neuropeptide FF: current status and structural insights.
Future Med. Chem. 4(9) , 1085-92, (2012) Neuropeptide FF (NPFF) was first isolated from the bovine brain in 1985 and is linked with a variety of biological activities. NPFF, which belongs to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2)... |
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Opposite control of body temperature by NPFF1 and NPFF2 receptors in mice.
Neuropeptides 44(5) , 453-6, (2010) Neuropeptide FF (NPFF) is a neurotransmitter known to modulate opioid functions. This study investigates the effects of RF9, a new antagonist of NPFF receptors, on the roles of NPFF1 and NPFF2 receptors in thermoregulation in mice. RF9 (10 nmol) injected into... |
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Crypteins derived from the mouse neuropeptide FF (NPFF)A precursor display NPFF-like effects in nociceptive tests in mice.
Peptides 36(1) , 17-22, (2012) NPFF precursor, pro-NPFF(A) contains three known bioactive sequences: NPFF (FLFQPQRF-NH(2)), neuropeptide AF (NPAF; AGEGLSSPFWSLAAPQRF-NH(2)) and neuropeptide SF (NPSF; SLAAPQRF-NH(2)). The key-feature of these fragments is their common PQRF-amidated sequence... |
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Characterization of two novel tritiated radioligands for labelling Neuropeptide FF (NPFF1and NPFF2) receptors
Neurochem. Int. 55(8) , 815-9, (2009) The binding characteristics of [ 3H]-NPVF and [ 3H]-EYF, the two first tritiated probes for the respective labelling of NPFF 1 and NPFF 2 receptors, are presented. In membranes from CHO cells transfected with the human NPFF 1 receptor, [ 3H]-NPVF labelled one... |
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Modulation by Neuropeptide FF of the interaction of Mu-opioid (MOP) receptor with G-proteins
Neurochem. Int. 56(6-7) , 768-73, (2010) The Neuropeptide FF (NPFF) system is known to modulate the effects of opioids in vivo and in vitro. In the present study, we have investigated the effect of NPFF agonists on the coupling of the Mu-opioid (MOP) receptor to G-proteins in a model of SH-SY5Y cell... |
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Central administration of neuropeptide FF and related peptides attenuate systemic morphine analgesia in mice.
Protein Pept. Lett. 18(4) , 403-9, (2011) Neuropeptide FF (NPFF) belongs to an opioid-modulating peptide family. NPFF has been reported to play important roles in the control of pain and analgesia through interactions with the opioid system. However, very few studies examined the effect of supraspina... |
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Anoretic effects of neuropeptide FF are mediated via central mu and kappa subtypes of opioid receptors and receptor ligands.
Gen. Comp. Endocrinol. 159(2-3) , 125-9, (2008) Recently, we demonstrated that neuropeptide FF (NPFF) causes anorexigenic effects in chicks that were associated with the hypothalamus. The present study was designed to better understand some of the central mechanisms that mediate these effects. Co-injection... |