Ac-DEVD-CHO
Ac-DEVD-CHO structure
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Common Name | Ac-DEVD-CHO | ||
|---|---|---|---|---|
| CAS Number | 169332-60-9 | Molecular Weight | 502.47200 | |
| Density | 1.374g/cm3 | Boiling Point | 1021.1ºC at 760mmHg | |
| Molecular Formula | C20H30N4O11 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 571.3ºC | |
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The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production.
Biochem. Biophys. Res. Commun. 463 , 545-50, (2015) In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide production, exerted potent anti-proliferative and pro-apop... |
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Artesunate-enhanced apoptosis of human high-risk myelodysplastic cells induced by the DNA methyltransferase inhibitor decitabine.
Oncol. Lett. 9 , 2449-2454, (2015) The present study aimed to investigate whether artesunate (ART) could enhance the rate of apoptosis induced by decitabine (DAC) in the high-risk myelodysplastic syndrome (MDS) SKM-1 cell line, and examine the potential underlying mechanisms. The cytotoxicity ... |
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Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells.
Nature Chemistry 6(10) , 885-92, (2014) Anion transporters based on small molecules have received attention as therapeutic agents because of their potential to disrupt cellular ion homeostasis. However, a direct correlation between a change in cellular chloride anion concentration and cytotoxicity ... |
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Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors.
PLoS ONE 10(3) , e0120510, (2015) Epidemiologic studies have demonstrated important links between air pollution and asthma. Amongst these pollutants, environmental cigarette smoke is a risk factor both for asthma pathogenesis and exacerbation. As the barrier to the inhaled environment, the br... |
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Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine.
Oncotarget 6 , 14596-613, (2015) Ewing's sarcoma (ES) is the second most common bone cancer in children and young people. Edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) is the prototype of a family of synthetic antitumor compounds, collectively known as alkylphospholipid ... |
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Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo.
Toxicol. Sci. 141(2) , 453-64, (2014) Hepatocyte (HPC) apoptosis occurs in association with hepatotoxic responses and chronic liver disease, and is coupled to activation of the blood coagulation cascade. HPCs have been shown to express tissue factor (TF), the primary activator of blood coagulatio... |
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Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis.
J. Biol. Chem. 290 , 14077-90, (2015) Ribonucleotide reductase (RnR) is a key enzyme synthesizing deoxyribonucleotides for DNA replication and repair. In mammals, the R1 catalytic subunit forms an active complex with either one of the two small subunits R2 and p53R2. Expression of R2 is S phase-s... |
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Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.
Food Chem. Toxicol. 75 , 173-86, (2015) Furazolidone (FZD), a synthetic nitrofuran with a broad spectrum of antimicrobial activities, has been shown to be genotoxic and potentially carcinogenic in several types of cells. However, the proper molecular mechanisms of FZD toxicity remain unclear. This ... |
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Selenite induces DNA damage and specific mitochondrial degeneration in human bladder cancer cells.
Toxicol. In Vitro 32 , 105-14, (2016) We have investigated the cytotoxicity and specific effects of selenite in human bladder cancer cell line RT-112 and its clonogenic variant RT-112 HB. Selenite inhibited cell growth and proliferation in both cell lines. Treated cells developed extensive vacuol... |
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Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway.
Environ. Toxicol. Pharmacol. 41 , 167-79, (2016) Thapsigargin (TG), is widely used to induce endoplasmic reticular stress. Treated with TG for a long time, cells suffer the unfolded protein response (UPR) to elude apoptosis, but may activate autophagy. However, the switch between autophagy and apoptosis is ... |