Acetylthiosuccinic anhydride

Acetylthiosuccinic anhydride Structure
Acetylthiosuccinic anhydride structure
Common Name Acetylthiosuccinic anhydride
CAS Number 6953-60-2 Molecular Weight 174.174
Density 1.4±0.1 g/cm3 Boiling Point 354.3±31.0 °C at 760 mmHg
Molecular Formula C6H6O4S Melting Point 83-86 °C(lit.)
MSDS Chinese USA Flash Point 188.3±12.9 °C
Symbol GHS07
GHS07
Signal Word Warning

Activity of recombinant mitogillin and mitogillin immunoconjugates.

J. Biol. Chem. 267(23) , 16712-16718, (1992)

A synthetic gene for the Aspergillus protein toxin mitogillin has been synthesized and expressed in Escherichia coli. The recombinant mitogillin is a potent inhibitor of protein synthesis in vitro with an IC50 of 9.7 pM. Immunoconjugates of recombinant mitogi...

Sites of metal deposition in the cell wall of Bacillus subtilis.

J. Bacteriol. 141(2) , 876-87, (1980)

Amine and carboxyl groups of the cell wall of Bacillus subtilis were chemically modified individually to neutralize their electrochemical charge for determination of their contribution to the metal uptake process. Mild alkali treatment removed ca. 94% of the ...

Quenching and blinking of fluorescence of a single dye molecule bound to gold nanoparticles.

J. Phys. Chem. B 110(33) , 16491-8, (2006)

A fluorescein derivative (SAMSA) bound to gold nanoparticles of different diameters is investigated by time-resolved fluorescence at the single molecule level in a wide dynamic range, from nanosecond to second time scale. The significant decrease of both SAMS...

Thiol-containing cross-linking agent with enhanced steric hindrance.

Bioconjug. Chem. 1(6) , 400-10, (1990)

Ricin A chain immunotoxins disulfide cross-linked with conventional, sterically unhindered reagents have unsatisfactorily short circulating life times in vivo. (Acetylthio)succinic anhydride, a thiolating reagent with partial steric hindrance of the sulfur at...

Synthesis of hyaluronan haloacetates and biology of novel cross-linker-free synthetic extracellular matrix hydrogels.

Biomacromolecules 8(9) , 2821-8, (2007)

Hyaluronan (HA) derivatives containing thiol-reactive electrophilic esters were prepared to react with thiol-modified macromolecules to give cross-linker-free hydrogels. Specifically, HA was converted to two haloacetate derivatives, HA bromoacetate (HABA) and...

Hermanson GT, Hermanson GT

Bioconjugate Techniques

Introduction of sulfhydryl groups into proteins using acetylmercaptosuccinic anhydride Klotz IM, et al.

Arch. Biochem. Biophys. 96(3) , 605-612, (1932)

Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin. Shechter Y, et al.

Proc. Natl. Acad. Sci. U. S. A. 75(5) , 2135-2139, (1978)