4-Amidinophenylmethanesulfonyl fluoride hydrochloride
4-Amidinophenylmethanesulfonyl fluoride hydrochloride structure
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Common Name | 4-Amidinophenylmethanesulfonyl fluoride hydrochloride | ||
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| CAS Number | 74938-88-8 | Molecular Weight | 252.69 | |
| Density | N/A | Boiling Point | 405.2ºC at 760 mmHg | |
| Molecular Formula | C8H10ClFN2O2S | Melting Point | ~205 °C (dec.) | |
| MSDS | USA | Flash Point | 198.8ºC | |
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In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents.
J. Pharmacol. Exp. Ther. 352(3) , 471-9, (2015) Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. We evaluated the in vivo pharmacological profile of a potent and selective PDE10A inhibitor, TAK-063 (1-[2-fluoro-4-(1H-pyrazol-1-... |
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Zinc binding activity of human metapneumovirus M2-1 protein is indispensable for viral replication and pathogenesis in vivo.
J. Virol. 89 , 6391-405, (2015) Human metapneumovirus (hMPV) is a member of the Pneumovirinae subfamily in the Paramyxoviridae family that causes respiratory tract infections in humans. Unlike members of the Paramyxovirinae subfamily, the polymerase complex of pneumoviruses requires an addi... |
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APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription.
FEBS Lett. 589(4) , 532-9, (2015) APPL1 is a multifunctional endocytic adaptor which acts at different steps of various signaling pathways. Here we report that APPL1 interacts with Dvl2, a protein known to activate the canonical and non-canonical Wnt pathways. APPL1 synergizes with Dvl2 and p... |
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Comparison of arterial pressure and plasma ANG II responses to three methods of subcutaneous ANG II administration.
Am. J. Physiol. Heart Circ. Physiol. 307(5) , H670-9, (2014) Angiotensin II (ANG II)-induced hypertension is a commonly studied model of experimental hypertension, particularly in rodents, and is often generated by subcutaneous delivery of ANG II using Alzet osmotic minipumps chronically implanted under the skin. We ha... |
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Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma.
Oncotarget 5(4) , 882-93, (2014) Glioblastoma remains one of the deadliest of human cancers, with most patients succumbing to the disease within two years of diagnosis. The available data suggest that simultaneous inactivation of critical nodes within the glioblastoma molecular circuitry wil... |
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New insights into the spatiotemporal localization of prothrombinase in vivo.
Blood 124(11) , 1705-14, (2014) The membrane-dependent interaction of factor Xa (FXa) with factor Va (FVa) forms prothrombinase and drives thrombin formation essential for hemostasis. Activated platelets are considered to provide the primary biological surface to support prothrombinase func... |
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Identification of an essential serine residue in glucagon: implication for an active site triad.
Proc. Natl. Acad. Sci. U. S. A. 91 , 454-458, (1994) Several glucagon analogs containing substitutions for serine have been synthesized to assess the role of the four serine residues in the hormone. The strategic importance of His1 has been confirmed, and we have previously identified an aspartic acid critical ... |
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(p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitor of serine proteases.
Biochemistry 19 , 4859, (1980) p-(Amidinophenyl)methanesulfonyl fluoride (p-APMSF) has been synthesized and shown to be a specific, irreversible inhibitor of the class of plasma serine proteases which demonstrate substrate specificity for the positively charged side chains of the amino aci... |