Nimodipine
Nimodipine structure
|
Common Name | Nimodipine | ||
|---|---|---|---|---|
| CAS Number | 66085-59-4 | Molecular Weight | 418.440 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 534.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H26N2O7 | Melting Point | 125°C | |
| MSDS | Chinese USA | Flash Point | 277.3±30.1 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
|
Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds.
Chem. Senses 39(6) , 471-87, (2014) Astringency is an everyday sensory experience best described as a dry mouthfeel typically elicited by phenol-rich alimentary products like tea and wine. The neural correlates and cellular mechanisms of astringency perception are still not well understood. We ... |
|
|
Neuroprotective effects of oxysophocarpine on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion.
Pharm. Biol. 52(8) , 1052-9, (2014) Oxysophocarpine (OSC), a quinolizidine alkaloid extracted from leguminous plants of the genus Robinia, is traditionally used for various diseases including neuronal disorders.This study investigated the protective effects of OSC on neonatal rat primary-cultur... |
|
|
Protective effects of aloperine on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion.
J. Nat. Med. 69 , 575-83, (2015) Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons i... |
|
|
Local anesthetic lidocaine inhibits TRPM7 current and TRPM7-mediated zinc toxicity.
CNS Neurosci. Ther. 21(1) , 32-9, (2014) Previous study demonstrated that overstimulation of TRPM7 substantially contributes to zinc-mediated neuronal toxicity. Inhibition of TRPM7 activity and TRPM7-mediated intracellular Zn(2+) accumulation may represent a promising strategy in the treatment of st... |
|
|
Characterization of zinc uptake by mouse primary cultured astrocytes and microglia.
Metallomics 7 , 1067-77, (2015) To elucidate the regulatory mechanism for extracellular zinc in the CNS, we examined the zinc uptake characteristics in mouse astrocytes and microglia. Zinc was taken up into the two cell types time-dependently, and the cell-to-medium concentration (C/M) rati... |
|
|
Oligodendrocytes Are Targets of HIV-1 Tat: NMDA and AMPA Receptor-Mediated Effects on Survival and Development.
J. Neurosci. 35 , 11384-98, (2015) Myelin pallor in HIV(+) individuals can occur very early during the disease process. While myelin damage might partly originate from HIV-induced vascular changes, the timing suggests that myelin and/or oligodendrocytes (OLs) may be directly affected. Histolog... |
|
|
Activation of InsP₃ receptors is sufficient for inducing graded intrinsic plasticity in rat hippocampal pyramidal neurons.
J. Neurophysiol. 113 , 2002-13, (2015) The synaptic plasticity literature has focused on establishing necessity and sufficiency as two essential and distinct features in causally relating a signaling molecule to plasticity induction, an approach that has been surprisingly lacking in the intrinsic ... |
|
|
Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop.
Neural Regen. Res. 10 , 925-31, (2015) Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 ... |
|
|
A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.
Nat. Commun. 5 , 5683, (2014) Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies dep... |
|
|
Native store-operated calcium channels are functionally expressed in mouse spinal cord dorsal horn neurons and regulate resting calcium homeostasis.
J. Physiol. 592(Pt 16) , 3443-61, (2014) Store-operated calcium channels (SOCs) are calcium-selective cation channels that mediate calcium entry in many different cell types. Store-operated calcium entry (SOCE) is involved in various cellular functions. Increasing evidence suggests that impairment o... |