Olanzapine
Olanzapine structure
|
Common Name | Olanzapine | ||
|---|---|---|---|---|
| CAS Number | 132539-06-1 | Molecular Weight | 312.432 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 476.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H20N4S | Melting Point | 195°C | |
| MSDS | USA | Flash Point | 241.7±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations.
Drug Dev. Ind. Pharm. 41(3) , 502-14, (2015) Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well as for the assessment of changes in physical form of drug m... |
|
|
Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
|
|
Olanzapine inhibits the proliferation and induces the differentiation of glioma stem-like cells through modulating the Wnt signaling pathway in vitro.
Eur. Rev. Med. Pharmacol. Sci. 19 , 2406-15, (2015) Olanzapine, a D2/5-HT2 antagonist, is often used as an atypical antipsychotic drug in clinical. Previous research has found its new pharmacological influence on enhancing the differentiation of neural stem cells (NSCs) to oligodendrocyte-like cells (ODLCs). G... |
|
|
Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range.
J. Pharmacol. Sci. 127(3) , 326-31, (2015) Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 re... |
|
|
In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents.
J. Pharmacol. Exp. Ther. 352(3) , 471-9, (2015) Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. We evaluated the in vivo pharmacological profile of a potent and selective PDE10A inhibitor, TAK-063 (1-[2-fluoro-4-(1H-pyrazol-1-... |
|
|
Analysis of drugs in plasma samples from schizophrenic patients by column-switching liquid chromatography-tandem mass spectrometry with organic-inorganic hybrid cyanopropyl monolithic column.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 993-994 , 26-35, (2015) This study reports on the development of a rapid, selective, and sensitive column-switching liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to analyze sixteen drugs (antidepressants, anticonvulsants, anxiolytics, and antipsychotics) in plasma... |
|
|
Effect of clozapine and olanzapine on neutrophil kinetics: implications for drug-induced agranulocytosis.
Chem. Res. Toxicol. 27(7) , 1104-8, (2014) Clozapine is effective in the treatment of schizophrenia; however, its use is limited by a relatively high incidence of idiosyncratic agranulocytosis. The mechanism of clozapine-induced idiosyncratic agranulocytosis is unknown. Although most patients treated ... |
|
|
The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry.
Drug Test. Anal. 7 , 502-11, (2015) Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has conse... |
|
|
Hybrid silica monolith for microextraction by packed sorbent to determine drugs from plasma samples by liquid chromatography-tandem mass spectrometry.
Talanta 140 , 166-75, (2015) The present study (1) reports on the synthesis of two hybrid silica monoliths functionalized with aminopropyl or cyanopropyl groups by the sol-gel process; (2) evaluates these monoliths as selective stationary phase for microextraction by packed sorbent (MEPS... |
|
|
MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol.
Behav. Pharmacol. 26 , 748-65, (2015) Deficiencies in social activities are hallmarks of numerous brain disorders. With respect to schizophrenia, social withdrawal belongs to the category of negative symptoms and is associated with deficits in the cognitive domain. Here, we used the N-methyl-D-as... |