N,N-Diethylaniline

N,N-Diethylaniline Structure
N,N-Diethylaniline structure
Common Name N,N-Diethylaniline
CAS Number 91-66-7 Molecular Weight 149.233
Density 0.9±0.1 g/cm3 Boiling Point 213.5±9.0 °C at 760 mmHg
Molecular Formula C10H15N Melting Point -38 °C
MSDS Chinese USA Flash Point 97.8±0.0 °C
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger

Polyoxometalates--potent and selective ecto-nucleotidase inhibitors.

Biochem. Pharmacol. 93(2) , 171-81, (2015)

Polyoxometalates (POMs) are inorganic cluster metal complexes that possess versatile biological activities, including antibacterial, anticancer, antidiabetic, and antiviral effects. Their mechanisms of action at the molecular level are largely unknown. Howeve...

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated cap...

Exploring the enantioseparation of amino-naphthol analogues by supercritical fluid chromatography.

J. Chromatogr. A. 1387 , 123-33, (2015)

The direct separation of the enantiomers of 1-(α-aminoarylmethyl)-2-naphthol, 1-(α-aminoalkyl)-2-naphthol, 2-(α-aminoarylmethyl)-1-naphthol analogues and 2-(1-amino-2-methylpropyl)-1-naphthol) was investigated in supercritical fluid chromatography. Five comme...

Investigation of the structure-selectivity relationships and van't Hoff analysis of chromatographic stereoisomer separations of unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids on Cinchona alkaloid-based chiral stationary phases.

J. Chromatogr. A. 1384 , 67-75, (2015)

The enantiomers of four unusual, rather rigid isoxazoline-fused 2-aminocyclopentanecarboxylic acids were directly separated on a quinine- or a quinidine-based zwitterionic ion-exchanger as chiral selector. The effects of the mobile phase composition, the stru...

A novel UV degradation product of Ebastine: isolation and characterization using Q-TOF, NMR, IR and computational chemistry.

J. Pharm. Biomed. Anal. 107 , 488-94, (2015)

Forced degradation of Ebastine (1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy) piperidin-1-yl)butan-1-one) drug substance in ultraviolet light condition resulted into an unknown significant degradation product. This degradation product was analyzed us...

Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B.

MBio 6 , e00206-15, (2015)

Nitric oxide (NO) plays an important signaling role in all domains of life. Many bacteria contain a heme-nitric oxide/oxygen binding (H-NOX) protein that selectively binds NO. These H-NOX proteins often act as sensors that regulate histidine kinase (HK) activ...

PHEA-PLA biocompatible nanoparticles by technique of solvent evaporation from multiple emulsions.

Int. J. Pharm. 495 , 719-27, (2015)

Nanocarriers of amphiphilic polymeric materials represent versatile delivery systems for poorly water soluble drugs. In this work the technique of solvent evaporation from multiple emulsions was applied to produce nanovectors based on new amphiphilic copolyme...

Platelet-derived HMGB1 is a critical mediator of thrombosis.

J. Clin. Invest. 125 , 4638-54, (2015)

Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular pattern molecule high-mobility group box 1 (HMGB1) is upregulat...

Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age.

Neurobiol. Aging 36(1) , 134-48, (2014)

The entorhinal cortex (EC) is one of the first brain areas to display neuropathology in Alzheimer's disease. A mouse model which simulates amyloid-β (Aβ) neuropathology, the Tg2576 mouse, was used to address these early changes. Here, we show EC abnormalities...

An electrochemical immunoassay for the screening of celiac disease in saliva samples.

Anal. Bioanal. Chem 407 , 7189-96, (2015)

A highly sensitive electrochemical immunoassay for the initial diagnosis of celiac disease (CD) in saliva samples that overcomes the problems related to its high viscosity and to the low concentration of anti-transglutaminase antigen (tTG) IgA in this medium ...