Cloperastine hydrochloride
Cloperastine hydrochloride structure
|
Common Name | Cloperastine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 14984-68-0 | Molecular Weight | 366.325 | |
| Density | N/A | Boiling Point | 84°C 35mm | |
| Molecular Formula | C20H25Cl2NO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 210.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
[Novel antidepressant-like action of drugs possessing GIRK channel blocking action in rats].
Yakugaku Zasshi 130(5) , 699-705, (2010) We have previously found that antitussive drugs inhibit G protein-coupled inwardly rectifying potassium (GIRK) channel currents in brain neurons. Potassium efflux through GIRK channels causes membrane hyperpolarization, and thus plays an important role in the... |
|
|
Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs.
J. Pharmacol. Sci. 120(3) , 165-75, (2012) Cloperastine is an antitussive drug, which can be received as an over-the-counter cold medicine. The chemical structure of cloperastine is quite similar to that of the antihistamine drug diphenhydramine, which is reported to inhibit hERG K⁺ channels and clini... |
|
|
Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.
Drugs Exp. Clin. Res. 30(4) , 133-41, (2004) The medical and social impact of cough is substantial. Current antitussive agents at effective doses have adverse events such as drowsiness, nausea and constipation that limit their use. There is also recent evidence that standard antitussive agents, such as ... |
|
|
Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry.
J. Pharm. Biomed. Anal. 51(3) , 716-22, (2010) A rapid and sensitive method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma has been developed and validated. Af... |
|
|
[Effect of cloperastine on muco-ciliary clearance].
Arch. Monaldi 38(5-6) , 219-23, (1983)
|
|
|
[Clinical study of a new antitussive: cloperastine].
Arch. Monaldi 38(5-6) , 209-18, (1983)
|
|
|
[The pharmacologic activity of 1(2-(p-chloro-alpha-phenylbenzyloxy)ethyl)piperidine (cloperastine)].
Boll. Chim. Farm. 122(8) , 384-92, (1983)
|
|
|
[Cloperastine fendizoate in the treatment of cough-producing diseases in pediatrics].
Minerva Pediatr. 40(5) , 283-6, (1988)
|
|
|
Clinical trials with the new antitussive levodropropizine in adult bronchitic patients.
Arzneimittelforschung 38(8) , 1163-6, (1988) The results of 6 clinical trials involving a total of 174 patients are reported. Levodropropizine (S(-)-3-(4-phenyl-piperazin-1-yl)-propane-1,2-diol, DF 526) was compared in double-blind manner with placebo, morclofone and cloperastine. The antitussive activi... |
|
|
Effects of solid-state reaction between paracetamol and cloperastine hydrochloride on the pharmaceutical properties of their preparations.
Int. J. Pharm. 335(1-2) , 12-9, (2007) Tablets containing both paracetamol (PM) and cloperastine hydrochloride (CLH) in a combination formulation prepared by standard vertical granulation technology were found to have altered pharmaceutical properties. The hardness and disintegration time of table... |