Paroxetine hydrochloride hydrate
Paroxetine hydrochloride hydrate structure
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Common Name | Paroxetine hydrochloride hydrate | ||
|---|---|---|---|---|
| CAS Number | 110429-35-1 | Molecular Weight | 374.83 | |
| Density | 1.213g/cm3 | Boiling Point | 451.7ºC at 760mmHg | |
| Molecular Formula | C19H22ClFNO3.5 | Melting Point | 121-131ºC | |
| MSDS | Chinese USA | Flash Point | 227ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A new SiF-Dipropargyl glycerol scaffold as a versatile prosthetic group to design dimeric radioligands: synthesis of the [(18) F]BMPPSiF tracer to image serotonin receptors.
ChemMedChem 9(2) , 337-49, (2014) A novel SiX-dipropargyl glycerol scaffold (X: H, F, or (18) F) was developed as a versatile prosthetic group that provides technical advantages for the preparation of dimeric radioligands based on silicon fluoride acceptor pre- or post-labeling with fluorine-... |
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A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.
J. Clin. Psychopharmacol. 33(1) , 3-10, (2013) The potential for iloperidone, a D2/5-HT2A antipsychotic, to affect the heart rate-corrected QT interval (QTc) was assessed in the absence and presence of metabolic inhibitors in a randomized, open-label, multicenter study. QT interval prolongation by medicat... |
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A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.
Sci. Transl. Med. 7 , 290ra89, (2015) Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical ... |
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Chronic angle-closure glaucoma related to paroxetine treatment.
Semin. Ophthalmol. 28(4) , 244-6, (2013) To present a unique case of a 33-year-old woman using paroxetine who presented with acute unilateral visual loss due to chronic angle-closure glaucoma.Case report.A 33-year-old women who had been under paroxetine treatment for the past four months presented a... |
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Paroxetine hydrochloride: polymorphs and solvatomorphs.
Profiles Drug Subst. Excip. Relat. Methodol. 38 , 407-21, (2013) The polymorphic (crystal systems for which a substance can exist in structures defined by different unit cells, and where each of the forms has the same elemental composition) and solvatomorphic (systems where the crystal structures of the substance are defin... |
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Paroxetine hydrochloride.
Profiles Drug Subst. Excip. Relat. Methodol. 38 , 367-406, (2013) Paroxetine hydrochloride (3S-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride (or (-)-(3S,4R)-(4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)-phenoxy]methyl]piperidine hydrochloride), a phenylpiperidine derivative, is a sele... |
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GSK paid smaller companies to delay generic versions of paroxetine, says fair trade body.
BMJ 346 , f2566, (2013)
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Teaching an old drug new tricks: can paroxetine ease the burden of cardiovascular disease in diabetes?
Diabetes 62(3) , 698-700, (2013)
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5-HTTLPR rs25531A > G differentially influence paroxetine and fluvoxamine antidepressant efficacy: a randomized, controlled trial.
J. Clin. Psychopharmacol. 33(1) , 131-2, (2013)
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Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation.
PLoS ONE 8(3) , e59187, (2013) New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of modern reactions from the stage of synthe... |