(+)-B-HYDRASTINE HCL
(+)-B-HYDRASTINE HCL structure
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Common Name | (+)-B-HYDRASTINE HCL | ||
|---|---|---|---|---|
| CAS Number | 5936-28-7 | Molecular Weight | 419.85500 | |
| Density | N/A | Boiling Point | 548.8ºC at 760 mmHg | |
| Molecular Formula | C21H22ClNO6 | Melting Point | 115ºC | |
| MSDS | N/A | Flash Point | 285.7ºC | |
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Expanding the repertoire of small molecule transcriptional activation domains.
Bioorg. Med. Chem. 17 , 1034-43, (2009) Molecules that can reconstitute the function of transcriptional activators hold enormous potential as therapeutic agents and as mechanistic probes. Previously we described an isoxazolidine bearing functional groups similar to natural transcriptional activator... |
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Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism.
J. Neurophysiol. 86(5) , 2363-73, (2001) The discharge patterns of respiratory neurons of the caudal ventral respiratory group (cVRG) appear to be subject to potent GABAergic gain modulation. Local application of the GABA(A) receptor antagonist bicuculline methochloride amplifies the underlying disc... |
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Effects of (1R,9S)-beta-hydrastine on l-DOPA-induced cytotoxicity in PC12 cells.
Eur. J. Pharmacol. 488(1-3) , 71-7, (2004) (1R,9S)-beta-Hydrastine in lower concentrations of 10-50 microM inhibits dopamine biosynthesis in PC12 cells. In this study, the effects of (1R,9S)-beta-hydrastine on L-DOPA (L-3,4-dihydroxyphenylalanine)-induced cytotoxicity in PC12 cells were investigated. ... |
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Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: collaborative study.
J. AOAC Int. 91(4) , 694-701, (2008) A multilaboratory collaborative study was conducted on a high-performance liquid chromatographic (HPLC) method utilizing UV detection, previously validated using AOAC single-laboratory validation guidelines for determination of hydrastine and berberine in gol... |
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A validated high performance liquid chromatographic method for the analysis of Goldenseal.
J. Pharm. Pharmacol. 54(3) , 435-9, (2002) Goldenseal (Hydrastis canadensis L.) has emerged as one of the top ten herbal supplements on the worldwide market. A rapid, simple and validated high performance liquid chromatographic method, with photodiode array detection, has been developed for the analys... |
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Pharmacological properties of nicotinic acetylcholine receptors in isolated Locusta migratoria neurones.
Microsc. Res. Tech. 56(4) , 249-55, (2002) Mechanically dissociated neuronal cell bodies from the thoracic ganglia of Locusta migratoria were viable in culture conditions for up to 2 days and were voltage-clamped to record the effects of GABAergic drugs and physostigmine on the membrane conductance an... |
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Analysis of goldenseal, Hydrastis canadensis L., and related alkaloids in urine using HPLC with UV detection.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 880(1) , 114-8, (2012) A screening method was developed to extract and detect berberine and hydrastine alkaloids from goldenseal root powder and urine samples using HPLC with UV detection. The isocratic method was developed to detect alkaloids in 5 mL of urine prior to drug screeni... |
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Microbial transformation of the phthalideisoquinoline alkaloid, (-)-beta-hydrastine.
Nat. Prod. Res. 17(4) , 269-74, (2003) The phthalideisoquinoline alkaloid (-)-beta-hydrastine is one of the main active constituents of the medicinal plant, Hydrastis canadensis, which is used in many dietary supplements intended to enhance the immune system. Treatment of hydrastine with the ferme... |
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Effects of (1R,9S)-beta-hydrastine on intracellular calcium concentration in PC12 cells.
Biol. Pharm. Bull. 30(8) , 1547-50, (2007) (1R,9S)-beta-hydrastine (BHS) decreases the basal intracellular Ca(2+) concentration ([Ca(2+)](i)) in PC12 cells.(5) This study examined the effects of (1R,9S)-BHS on [Ca(2+)](i) in PC12 cells. (1R,9S)-BHS at 10-100 microM in combination with a high extracell... |
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Inhibitory effects of (1R,9S)-beta-Hydrastine on calcium transport in PC12 cells.
Arch. Pharm. Res. 30(1) , 109-13, (2007) (1R,9S)-beta-Hydrastine (BHS), at 100 microM, has been shown to mainly reduce the K+-induced dopamine release and Ca2+ influx by blocking the L-type Ca2+ channel and inhibit the caffeine activated store-operated Ca2+ channels, but not those activated by thaps... |