promethazine hydrochloride
promethazine hydrochloride structure
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Common Name | promethazine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 58-33-3 | Molecular Weight | 320.880 | |
| Density | 1.131 g/cm3 | Boiling Point | 403.7ºC at 760 mmHg | |
| Molecular Formula | C17H21ClN2S | Melting Point | 230-232°C | |
| MSDS | Chinese USA | Flash Point | 198ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Probiotic properties of lactic acid bacteria isolated from water-buffalo mozzarella cheese.
Probiotics Antimicrob Proteins 6 , 141-56, (2014) This study evaluated the probiotic properties (stability at different pH values and bile salt concentration, auto-aggregation and co-aggregation, survival in the presence of antibiotics and commercial drugs, study of β-galactosidase production, evaluation of ... |
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The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.
Altern. Lab. Anim. 43 , 101-27, (2015) The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the human response to chemicals, cosmetics and other consumer prod... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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How Does High-Concentration Supplemental Perioperative Oxygen Influence Surgical Outcomes after Thyroid Surgery? A Prospective, Randomized, Double-Blind, Controlled, Monocentric Trial
J. Am. Coll. Surg. 220(5) , 921-33, (2015) Background Recurrent laryngeal nerve palsy (RLNP) and hypoparathyroidism are complications of thyroid surgery. The convalescence can depend on several factors (ie, pain, fatigue, nausea, and vomiting). Supplemental oxygen improves inflammatory and immune func... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery.
PLoS ONE 10(1) , e0116766, (2015) Acute and chronic pain conditions are often debilitating, inflicting severe physiological, emotional and economic costs and affect a large percentage of the global population. However, the development of therapeutic analgesic agents based primarily on targete... |
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Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay.
PLoS ONE 9(10) , e110800, (2014) Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulat... |
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Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.
Biochem. Pharmacol. 91(2) , 231-41, (2014) Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and sec... |