Propylthiouracil
Propylthiouracil structure
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Common Name | Propylthiouracil | ||
|---|---|---|---|---|
| CAS Number | 51-52-5 | Molecular Weight | 170.232 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 355.2±34.0 °C at 760 mmHg | |
| Molecular Formula | C7H10N2OS | Melting Point | 218-220 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 168.6±25.7 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction.
PLoS ONE 9(10) , e110373, (2014) Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved in r... |
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The evolutionary conservation of the A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafish.
BMC Evol. Biol. 15 , 22, (2015) The A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motifs (ADAMTS) enzymes comprise 19 mammalian zinc-dependent metalloproteinases (metzincins) with homologues in a wide range of invertebrates. ADAMTS enzymes have a broad range of funct... |
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Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma
Toxicol. Lett. 230(3) , 467-78, (2014) While conventional parameters used to detect hepatotoxicity in drug safety assessment studies are generally informative, the need remains for parameters that can detect the potential for hepatotoxicity at lower doses and/or at earlier time points. Previous wo... |
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[Cardiac arrest and cardial insuffiency as result of thyrotoxicosis].
Ugeskr. Laeg. 175(14) , 962-3, (2013) A 52-year-old woman, who had an out-of-hospital cardiac arrest, was resuscitated, intubated and transferred with cardiogenic shock to angioplasty of the right coronary artery. Afterwards the patient had normal biventricular function, but four days later she d... |
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Propylthiouracil-induced hypothyroidism during lactation alters leucine and mannose metabolism in rat cerebellar slices.
Exp. Biol. Med. (Maywood.) 238(1) , 31-6, (2013) Thyroid hormone deficiency during perinatal development results in significant alterations in neurological functions. The relationship between such events and brain metabolism is not completely understood. The aim of this study was to investigate the effects ... |
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Propylthiouracil versus methimazole in treatment of Graves' disease during pregnancy.
Ann. Pharmacother. 41(6) , 1018-22, (2007) To evaluate the evidence supporting the use of propylthiouracil (PTU) versus methimazole for the treatment of Graves' disease during pregnancy.An English-language literature search was conducted using MEDLINE (1966-March 2007). Identified articles were then r... |
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Teratogen update: antithyroid drugs-methimazole, carbimazole, and propylthiouracil.
Teratology 65(1) , 38-44, (2002)
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The effect of thyroidectomy and propylthiouracil-induced hypothyroidism on insulin secretion in male rats.
Horm. Metab. Res. 46(10) , 710-6, (2014) Data available on thyroid dysfunction and insulin secretion are inconsistent. The aim of this study was to assess the effect of hypothyroidism on insulin secretion, in vivo and in vitro, in rats. Adult Wistar male rats were divided into 4 groups, the control,... |
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Discrepant thyroid function test results in a 44-year-old man.
Clin. Chem. 59(12) , 1703-6, (2013)
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Propylthiouracil versus methimazole during pregnancy: an evolving tale of difficult choices.
J. Clin. Endocrinol. Metab. 98(11) , 4332-5, (2013)
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