2,2',4,4'-Tetrahydroxybenzophenone
2,2',4,4'-Tetrahydroxybenzophenone structure
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Common Name | 2,2',4,4'-Tetrahydroxybenzophenone | ||
|---|---|---|---|---|
| CAS Number | 131-55-5 | Molecular Weight | 246.215 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 531.2±25.0 °C at 760 mmHg | |
| Molecular Formula | C13H10O5 | Melting Point | 198-200 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 289.1±19.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.
Toxicol. Appl. Pharmacol. 280(1) , 60-9, (2014) Zebrafish, Danio rerio, is increasingly used as an animal model to study the effects of pharmaceuticals and environmental estrogens. As most of these estrogens have only been tested on human estrogen receptors (ERs), it is necessary to measure their effects o... |
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Metabolism of UV-filter benzophenone-3 by rat and human liver microsomes and its effect on endocrine-disrupting activity.
Toxicol. Appl. Pharmacol. 282(2) , 119-28, (2015) Benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is widely used as sunscreen for protection of human skin and hair from damage by ultraviolet (UV) radiation. In this study, we examined the metabolism of BP-3 by rat and human liver microsomes, and the es... |
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Ultra-preconcentration and determination of selected pharmaceutical and personal care products in different water matrices by solid-phase extraction combined with dispersive liquid-liquid microextraction prior to ultra high pressure liquid chromatography tandem mass spectrometry analysis.
J. Chromatogr. A. 1355 , 26-35, (2014) Pharmaceutical and personal care products (PPCPs) are one of the most important classes of emerging contaminants. The potential of ecological and environmental impacts associated with PPCPs are of particular concern because they continually penetrate the aqua... |
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Estrogenic activity of UV filter mixtures.
Toxicol. Appl. Pharmacol. 217(1) , 86-99, (2006) UV-absorbing chemicals (UV filters) are widely used for protection against UV radiation in sunscreens and in a variety of cosmetic products and materials. Depending on the breadth and factor of UV protection, they are added as single compounds or as a combina... |
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Cloud point extraction combined with micellar electrokinetic capillary chromatography determination of benzophenones in cosmetic matrix.
Electrophoresis 29(4) , 819-26, (2008) A method has been developed for the separation and determination of three hydrophobic benzophenones: 2,4-dihydroxybenzophenone (BP-1), 2,2'4,4'-tetrahydroxybenzophenone (BP-2), and 2-hydroxy-4-methoxybenzophenone (BP-3) in sunscreen by micellar electrokinetic... |
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Estrogenic activity of ternary UV filter mixtures in fish (Pimephales promelas) - an analysis with nonlinear isobolograms.
Toxicol. Appl. Pharmacol. 234(1) , 77-88, (2009) Numerous estrogenic compounds are present in aquatic environments, but currently it is not well understood how compounds that differ in maxima and slope of their individual dose-response curves contribute to the overall mixture effect. In order to better unde... |
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Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment.
Toxicology 205(1-2) , 87-93, (2004) The chemical industry has developed sun protection factor products, which contain a variety of so-called "UV screens", among others, benzophenones (BP). Based on the structure it can be assumed, that the variant BP2 may be a potent estrogenic endocrine disrup... |
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Pharmacokinetics and metabolism of benzophenone 2 in the rat.
Toxicology 245(1-2) , 11-7, (2008) Twelve derivatives of benzophenone (BP1-BP12) are widely used as UV-screens to protect industrial products from light induced damage. There is growing public concern about industrially produced chemicals that might interfere with hormonal signalling pathways,... |
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Effect of 2,2',4,4'-tetrahydroxybenzophenone (BP2) on steroidogenesis in testicular Leydig cells.
Toxicology 288(1-3) , 18-26, (2011) Endocrine disruptors (EDs) affect the function of animal reproductive systems. Recently, 2,2',4,4'-tetrahydroxybenzophenone (BP2), which is a component of UV protection products, was found to be an ED that interferes with the thyroid hormone (TH) axis. Howeve... |
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In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism.
J. Urol. 178(4 Pt 2) , 1637-42, (2007) Additives such as benzophenone-2 are commonly used in cosmetic products and food container plastics to filter out ultraviolet light. In pregnant women exposure may result in transplacental transfer of benzophenone-2 to fetuses. Benzophenone-2 is estrogenic in... |