Triclabendazole
Triclabendazole structure
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Common Name | Triclabendazole | ||
|---|---|---|---|---|
| CAS Number | 68786-66-3 | Molecular Weight | 359.658 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 495.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C14H9Cl3N2OS | Melting Point | 175-176°C | |
| MSDS | Chinese USA | Flash Point | 253.7±31.5 °C | |
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Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep.
Exp. Parasitol. 136 , 14-9, (2014) The flukicidal compound triclabendazole (TCBZ) has a complex metabolic pattern that includes the systemic presence of its sulphoxide (TCBZ.SO) and sulphone (TCBZ.SO2) metabolites, usually recovered from the bile of treated animals. The aim of the current work... |
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The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP.
Antimicrob. Agents Chemother. 56(7) , 3535-43, (2012) ABCG2/BCRP is an ATP-binding cassette transporter that extrudes compounds from cells in the intestine, liver, kidney, and other organs, such as the mammary gland, affecting pharmacokinetics and milk secretion of antibiotics, anticancer drugs, and other compou... |
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Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica.
Exp. Parasitol. 133(3) , 265-8, (2013) Isothermal microcalorimetry (IMC) is an analytical tool that continuously measures the heat flow generated by chemical, physical or biological processes. We have demonstrated that IMC is a useful tool to analyze drug effects on helminths, including adult Fasc... |
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Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon.
Exp. Parasitol. 136 , 59-62, (2014) In the current study, we identified five sheep flocks with fasciolosis in the province of León (northwestern Spain) in order to determine the anthelmintic resistance status to three commonly used anthelmintics, namely albendazole (ABZ), triclabendazole (TCBZ)... |
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Intraspecific mitochondrial DNA variation of Fasciola hepatica eggs from sheep with different level of anthelmintic resistance.
Parasitol. Res. 113(7) , 2733-41, (2014) In the current study, Fasciola hepatica strains of sheep with different degrees of resistance to anthelmintics were analyzed by sequencing the cytochrome C oxidase (COX1) and the NADH dehydrogenase (NAD1) subunits. The strains were as follows: LS, susceptible... |
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The in vitro anthelmintic effects of plumbagin on newly excysted and 4-weeks-old juvenile parasites of Fasciola gigantica.
Exp. Parasitol. 136 , 5-13, (2014) The effect of plumbagin (PB, 5-hydroxy-2-methyl-1,4-naphthoquinone) against newly excysted juveniles (NEJs) and 4-weeks-old immature parasites of Fasciola gigantica were compared with triclabendazole (TCZ). The anthelmintic efficacy of 1, 10 and 100μg/ml of P... |
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In vitro efficacy of triclabendazole and clorsulon against the larval stage of Echinococcus multilocularis.
Parasitol. Res. 112(4) , 1655-60, (2013) Alveolar echinococcosis (AE) caused by the cestode Echinococcus multilocularis (E. multilocularis) is endemic in wide areas of the Northern hemisphere. Untreated AE progresses and leads to death in more than 90% of cases. Until the advent of benzimidazoles, n... |
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Evaluation of the comparative efficacy of a moxidectin plus triclabendazole pour-on solution against adult and immature liver fluke, Fasciola hepatica, in cattle.
Vet. Parasitol. 189(2-4) , 227-32, (2012) The objective of this study was to evaluate the efficacy of a pour-on solution containing moxidectin plus triclabendazole (MOX plus TCBZ) against immature and adult stages of the liver fluke in cattle and compare the efficacy with other commercially available... |
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Living Fasciola hepatica in biliary tree: a case report.
Ann. Hepatol. 11(3) , 395-8, (2012) Here we report a rare case of living Fasciola hepatica in biliary tract. The patient was in acute phase of infection and treated successfully with 10 mg/kg oral triclabendazole after the fluke was extracted using endoscopic retrograde cholangiopancreatography... |
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Cases of human fascioliasis in India: tip of the iceberg.
J. Postgrad. Med. 58(2) , 150-2, (2012) This report presents two cases of human fascioliasis from different states in India. Although only few cases of human fascioliasis have been reported from India previously, both these cases were encountered within a span of three months at this tertiary care ... |