Parbendazole
Parbendazole structure
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Common Name | Parbendazole | ||
|---|---|---|---|---|
| CAS Number | 14255-87-9 | Molecular Weight | 247.293 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C13H17N3O2 | Melting Point | 255-257°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.
Nat. Commun. 6 , 6410, (2015) In this study, we show that several microtubule-destabilizing agents used for decades for treatment of cancer and other diseases also sensitize cancer cells to oncolytic rhabdoviruses and improve therapeutic outcomes in resistant murine cancer models. Drug-in... |
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Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014) A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of benzimidazoles in bovine milk by ultra high performance liqui... |
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Controlled tests of activity of several antiparasitic compounds against natural infections of Haemonchus contortus and other helminths in lambs from a flock established in 1962.
Am. J. Vet. Res. 54(3) , 406-10, (1993) Antiparasitic activity of several compounds was evaluated over a long period (about 25 years) in the same flock of sheep. Haemonchus contortus was of special interest, including its relation to drug resistance, especially to thiabendazole and other benzimidaz... |
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The effect of co-administration of parbendazole on the disposition of oxfendazole in sheep.
J. Vet. Pharmacol. Ther. 15(1) , 10-8, (1992) The effect of intraruminal administration of parbendazole (PBZ) on the flow rate of bile and the pharmacokinetic behaviour of oxfendazole (OFZ) was examined in sheep. PBZ given at 18, 9 and 4.5 mg/kg resulted in a dose-related reduction in bile flow rate whic... |
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Effect of parbendazole and piperazine adipate on the activity of some enzymes of Ascaridia galli and Heterakis gallinae.
Vet. Parasitol. 24(3-4) , 211-20, (1987) Adult Ascaridia galli and Heterakis gallinae obtained from the fowl (Gallus gallus) were treated in vitro with 10(-2) to 10(-5) M parbendazole and piperazine adipate for 10-60 min at 38 degrees C. Both the compounds at 10(-2) M caused mortality of A. galli an... |
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Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy.
J. Cell Sci. 49 , 195-204, (1981) We have shown that the benzimidazole carbamate, parbendazole, is a potent inhibitor of microtubule assembly in vitro and in vivo. Radiolabelled parbendazole was shown to bind to purified tubulin. Immunofluorescence studies using antitubulin antibody showed th... |
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Antiparasitic activity of parbendazole in critical tests in horses.
Am. J. Vet. Res. 41(1) , 123-4, (1980) Critical tests were conducted in 11 naturally infected horses to evaluate the anthelmintic activity of parbendazole. Single doses at the rates of 30, 20, 10, 5, or 2.5 mg/kg of body weight were administered by stomach tube to 1, 4, 2, 2, and 2 horses, respect... |
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Epidemiological aspects of the first outbreak of Baylisascaris procyonis larva migrans in rabbits in Japan.
J. Vet. Med. Sci. 65(4) , 453-7, (2003) Larva migrans caused by the common raccoon ascarid, Baylisascaris procyonis, is a zoonotic disease of critical importance in North America. Recently we encountered the first proven outbreak of this disease in Japan in domestic rabbits (Oryctolagus cuniculus) ... |
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Efficacy of a tribromosalan and parbendazole composition against adult Fasciola hepatica in sheep.
Res. Vet. Sci. 30(1) , 122-3, (1981)
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Potentiation by parbendazole of the anthelmintic activity of oxfendazole against natural infections of benzimidazole resistant nematodes.
Aust. Vet. J. 64(1) , 28-9, (1987)
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