Albendazole Oxide
Albendazole Oxide structure
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Common Name | Albendazole Oxide | ||
|---|---|---|---|---|
| CAS Number | 54029-12-8 | Molecular Weight | 281.331 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 357.3ºC at 760 mmHg | |
| Molecular Formula | C12H15N3O3S | Melting Point | 154-156ºC | |
| MSDS | Chinese USA | Flash Point | 169.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.
J. Anal. Toxicol. 39 , 374-86, (2015) Opioid-related mortality rates have escalated. Drug interactions may increase blood concentrations of the opioid. We therefore used human liver microsomes (HLMs) and cDNA-expressed human cytochrome P450s (rCYPs) to study in vitro inhibition of buprenorphine m... |
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Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry.
Anal. Bioanal. Chem 407 , 4423-35, (2015) Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the development and validation of a new high-throughput analytical ... |
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The transport of albendazole and albendazole sulphoxide in the lancet fluke (Dicrocoelium dendriticum).
Vet. Parasitol. 176(1) , 27-33, (2011) Albendazole (ABZ) is one of the most important benzimidazole compounds possessing high activity against the lancet fluke, Dicrocoelium dendriticum. ABZ sulphoxide (ABZ.SO) is the main molecule present in the bloodstream of an ABZ-treated host. The aim of this... |
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Stability of ricobendazole in aqueous solutions.
J. Pharm. Biomed. Anal. 49(5) , 1282-6, (2009) The chemical stability of ricobendazole (RBZ) was investigated using a stability-indicating high performance liquid chromatographic (HPLC) assay with ultraviolet detection. The degradation kinetics of RBZ in aqueous solution was evaluated as a function of pH,... |
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Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs.
J. Vet. Pharmacol. Ther. 34(2) , 136-41, (2011) New therapeutic strategies based on the search of alternative formulations of albendazole (ABZ) and albendazole sulphoxide (ABZSO) are under current development to optimize posology and antiparasite efficacy in dogs. In an incomplete block design, nine dogs w... |
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Inoperable cerebral alveolar echinococcosis controlled with high dosages of albendazole adjusted with monitoring of blood levels.
J. Travel Med. 19(3) , 198-201, (2012) Cerebral alveolar echinococcosis (AE) is a rare and difficult-to-treat zoonosis caused by Echinococcus multilocularis. A 29-year-old immigrant from Siberia with a past history of hepatic AE, presented with acute onset of grand mal seizures, weakness of the le... |
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Relative potency of albendazole and its sulfoxide metabolite in two in vitro tests for developmental toxicity: the rat whole embryo culture and the mouse embryonic stem cell test.
Reprod. Toxicol. 34(3) , 378-84, (2012) The benzimidazole carbamate albendazole (ABZ), a potent anthelmintic, is a teratogenic compound in rats. At present it is unclear to which degree this effect is caused by the parent compound or its major metabolite, albendazole sulfoxide (ASO). Both substance... |
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Albendazole and its metabolites in the breast milk of lactating women following a single oral dose of albendazole.
Br. J. Clin. Pharmacol. 68(5) , 737-42, (2009) Albendazole (ABZ) is used in several anthelminthic drug programs. ABZ side-effects are generally mild, but ABZ-induced pancytopenia may be serious. In filariasis programmes, it may be necessary to administer ABZ to breastfeeding women. Few data are available ... |
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Pharmacokinetics and tissue residues of hydrochloric acid albendazole sulfoxide and its metabolites in crucian carp (Carassius auratus) after oral administration.
Environ. Toxicol. Pharmacol. 33(2) , 197-204, (2012) The pharmacokinetics and residues elimination of hydrochloric acid albendazole sulfoxide (ABZSO) and its metabolites were studied in healthy crucian carp (Carassius auratus, 250 ± 30 g) kept at water temperatures of 10 °C and 25 °C. The concentrations of ABZS... |
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In vitro evaluation of the effects of cysticidal drugs in the Taenia crassiceps cysticerci ORF strain using the fluorescent CellTracker CMFDA.
Exp. Parasitol. 127(1) , 294-9, (2011) Using a murine model of cysticercosis caused by the Taenia crassiceps ORF strain, we developed a fluorescent quantitative evaluation of the action of two well known anti-helminthic drugs: albendazole sulfoxide and praziquantel. The fluorescence emitted by a b... |